Objective:To observe the effects of red coral (Corallium rubrum) on the healing of experimental rat fracture. Methods 12 rats were randomly selected as the blank group from sixty Wistar rats with SPF grade,and the radius fracture model on left forelimb was established in the other rats and verified by X-ray fluoroscopy. The successful modeling rats were randomly divided into the model group,positive drug group(150 μg/g),red coral groups with low-dose(150 μg/g) and high-dose(300 μg/g),12 rats in each group. From the second day after modeling,the drugs were given to the corresponding group by intragastric administration,once a day. After administration for 10,0,30 days,the fracture sites of rats in each group were evaluated by X-ray fluoroscopy and the histopathological changes were observed after HE staining. The serum contents of alkaline phosphatase (ALP), calcium (Ca) and phosphorus (P) were detected by enzyme linked immunosorbent assay(ELISA).  Results: The X-ray image showed that the edge line of fracture became blurred in the red coral group with high-dose after administration for 10 days；when administration for 20 days,the callus increased in the broken end of fracture and the density increased,the edge almost disappeared；when administration for 30 days,the callus filled with the fracture defect and complete healing was found. The HE staining of the fracture site showed that more fibrous tissue was found in the red coral group with high-dose,the callus formation rate was faster than that in the other groups,and the fracture healing time was shorter than that in the other groups. The serum levels of Ca and P were gradually increased in the red coral group with high-dose,and significantly higher than those in the model group,with statistical differences(P< 0.05). The content of ALP was increased first and then decreased in the red coral group with high-dose,and this change was more earlier and significant than that in the other groups, with statistical difference(P< 0.05).  Conclusion: The red coral can regulate the serum levels of ALP,Ca and P,accelerate calcium salt deposition,promote the increase of fibrous tissue in the fracture site of rats,accelerate the callus formation,shorten the healing period of fracture,which shows promotion effects on the healing and repair of fracture.