Clinical study on the influence of Chu’s Shuwei Recipe on pepsinogen and precancerous lesions of gastric cancer of spleen deficiency syndrome with stagnation of bloodstasis and heat

WU Yuan-min; ZHONG Hui-fang; CHU Ya-geng; WU Min-yu; HUANG Xiao-dong; HUANG Sheng-na

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Clinical study on the influence of Chu’s Shuwei Recipe on pepsinogen and precancerous lesions of gastric cancer of spleen deficiency syndrome with stagnation of bloodstasis and heat

更新时间：2022-08-31

- Clinical study on the influence of Chu’s Shuwei Recipe on pepsinogen and precancerous lesions of gastric cancer of spleen deficiency syndrome with stagnation of bloodstasis and heat
- Shanghai Journal of Traditional Chinese Medicine Vol. 51, Issue 3, Pages: 41-44(2017)
- 作者机构：
  
  1. 上海市浦东新区中医医院综合内科,上海,200136
  2. 上海市浦东新区中医医院脾胃科,上海,200136
- 作者简介：
- 基金信息：
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WU Yuan-min, ZHONG Hui-fang, CHU Ya-geng, et al. Clinical study on the influence of Chu’s Shuwei Recipe on pepsinogen and precancerous lesions of gastric cancer of spleen deficiency syndrome with stagnation of bloodstasis and heat. [J]. Shanghai Journal of Traditional Chinese Medicine 51(3):41-44(2017)
DOI：

WU Yuan-min, ZHONG Hui-fang, CHU Ya-geng, et al. Clinical study on the influence of Chu’s Shuwei Recipe on pepsinogen and precancerous lesions of gastric cancer of spleen deficiency syndrome with stagnation of bloodstasis and heat. [J]. Shanghai Journal of Traditional Chinese Medicine 51(3):41-44(2017) DOI：

摘要

目的：观察储氏纾萎方治疗脾虚兼瘀热互结型胃癌前病变的临床疗效。方法：将130例脾虚兼瘀热互结型胃癌前病变患者随机分为治疗组与对照组,每组65例。治疗组予储氏纾萎方,对照组予胃复春片。两组疗程均为3个月,观察中医证候积分、胃镜下黏膜病理积分、胃蛋白酶原(PGI、PGII)的变化情况。结果：①组间治疗后比较,纳呆消瘦、脘(腹)胀、脘(腹)痛、便溏、乏力、嗳气等中医证候的改善治疗组明显优于对照组(P<0.05)。②组间治疗后比较,萎缩、肠化、慢性炎症、活动性病理积分差异有统计学意义(P<0.05)。③组间治疗后比较,PGI、PGI/PGII水平差异有统计学意义,治疗组明显优于对照组(P<0.05)。结论：储氏纾萎方治疗脾虚兼瘀热互结型胃癌前病变的疗效满意,而调节血清PGI、PGII蛋白水平可能是本方起效的机制之一。

Abstract

Objective:To observe the clinical efficacy of Chu’s Shuwei Recipe in the treatment of precancerous lesions of gastric cancer of spleen deficiency syndrome with stagnation of blood stasis and heat. Methods130 patients of precancerous lesions of gastric cancer of spleen deficiency syndrome with stagnation of blood stasis and heat were randomly divided into the treatment group and control group,65 cases in each group. The treatment group was treated with Chu’s Shuwei Recipe and the control group was treated with Weifuchun tablets,with a course of 3 months. The TCM syndrome scores,the pathological scores of mucous membrane under the gastroscopy and the pepsinogen(PGI and PGII)were observed and compared. Results:①For the comparison between groups after treatment,the improvement on TCM syndrome(including anorexia,marasmus,abdominal swelling,abdominal pain,loose stool,weakness,belching and so on)in the treatment group was significantly better than that in the control group(P<0.05). ②For the comparison between groups after treatment,the differences on the pathological scores of atrophy,intestinal metaplasia,chronic inflammation and activity were statistically significant(P<0.05). ③For the comparison between groups after treatment,the differences on the levels of PGI and PGI/PGII were statistically significant,and the effect of the treatment on pepsinogen was significantly better than that of the control group(P<0.05). Conclusion:Chu’s Shuwei Recipe shows good effects in the treatment of precancerous lesions of gastric cancer of spleen deficiency syndrome with stagnation of blood stasis and heat. Regulation on serum protein level of PGI and PGII may be one of action mechanisms.

关键词

纾萎方胃癌前病变健脾清热化瘀中医药疗法起效机制

Keywords

Shuwei Recipeprecancerous lesionsstrengthening spleenclearing heat and removing blood stasistherapy of traditional Chinese medicineaction mechanism

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