Mechanism research of Chinese herbal monomers on reversing MDR1-induced tumor multidrug resistance

YUAN Yu-xia; YIN Pei-hao

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Mechanism research of Chinese herbal monomers on reversing MDR1-induced tumor multidrug resistance

更新时间：2022-08-31

- Mechanism research of Chinese herbal monomers on reversing MDR1-induced tumor multidrug resistance
- Shanghai Journal of Traditional Chinese Medicine Vol. 51, Issue 3, Pages: 96-98(2017)
- 作者机构：
  
  1. 上海中医药大学附属普陀医院普外科,上海,200062
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YUAN Yu-xia, YIN Pei-hao. Mechanism research of Chinese herbal monomers on reversing MDR1-induced tumor multidrug resistance. [J]. Shanghai Journal of Traditional Chinese Medicine 51(3):96-98(2017)
DOI：

YUAN Yu-xia, YIN Pei-hao. Mechanism research of Chinese herbal monomers on reversing MDR1-induced tumor multidrug resistance. [J]. Shanghai Journal of Traditional Chinese Medicine 51(3):96-98(2017) DOI：

摘要

综述中药单体逆转多药耐药基因1(MDR1)介导的肿瘤多药耐药机制研究进展。中药单体主要通过抑制MDR1基因的表达、抑制P-gp活性、抑制ATP酶、逆转凋亡抵制、抑制蛋白激酶活性等途径逆转MDR1介导的肿瘤多药耐药。

Abstract

This paper reviewed the mechanism of Chinese herbal monomers on reversing multidrug resistance gene 1 (MDR1) -induced tumor multidrug resistance. The mechanisms mainly include inhibiting the gene expression of MDR1, inhibiting the activity of P-gp, inhibiting ATP enzyme, reversing apoptosis, inhibit the activity of protein kinase and so on.

关键词

肿瘤多药耐药MDR1中药单体逆转

Keywords

tumormultidrug resistanceMDR1Chinese herbal monomersreverse

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