Research progress on intervention of traditional Chinese medicine in the signaling pathways of chemotherapy-induced hematopoietic stem cell senescence

CHEN Zhao-hui; LIN Xian-lei; LIN Sheng-you

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Research progress on intervention of traditional Chinese medicine in the signaling pathways of chemotherapy-induced hematopoietic stem cell senescence

更新时间：2022-08-31

- Research progress on intervention of traditional Chinese medicine in the signaling pathways of chemotherapy-induced hematopoietic stem cell senescence
- Shanghai Journal of Traditional Chinese Medicine Vol. 51, Issue 2, Pages: 89-92(2017)
- 作者机构：
  
  1. 浙江中医药大学第二临床医学院,浙江,杭州,310053
  2. 浙江省杭州市肿瘤医院,浙江,杭州,310002
- 作者简介：
- 基金信息：
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CHEN Zhao-hui, LIN Xian-lei, LIN Sheng-you. Research progress on intervention of traditional Chinese medicine in the signaling pathways of chemotherapy-induced hematopoietic stem cell senescence. [J]. Shanghai Journal of Traditional Chinese Medicine 51(2):89-92(2017)
DOI：

CHEN Zhao-hui, LIN Xian-lei, LIN Sheng-you. Research progress on intervention of traditional Chinese medicine in the signaling pathways of chemotherapy-induced hematopoietic stem cell senescence. [J]. Shanghai Journal of Traditional Chinese Medicine 51(2):89-92(2017) DOI：

摘要

综述中药对化疗致造血干细胞衰老信号通路干预的研究进展。化疗药物会造成骨髓抑制,目前认为造血干细胞衰老是骨髓抑制的关键机制,涉及最主要的信号通路为p53-p21(Cip1/Waf1)通路和p16Ink4a-RB通路,中医药被证实能够有效地干预造血干细胞衰老。

Abstract

This paper reviewed the research advance on intervention of traditional Chinese and western medicine in the signaling pathways of chemotherapy-induced hematopoietic stem cell senescence. Chemotherapy drugs can cause bone marrow suppression. At present,it is considered that the hematopoietic stem cell senescence is the key mechanism of bone marrow suppression,involving the main signaling pathway of p53-p21(Cip1/Waf1) pathway and p16Ink4a-RB pathway. It has confirmed that traditional Chinese medicine can effectively intervene on the hematopoietic stem cell senescence.

关键词

化疗骨髓抑制造血干细胞衰老信号通路

Keywords

chemotherapybone marrow suppressionhematopoietic stem cell senescencesignaling pathways

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