Objective:To study the efficacy of one-finger massage manipulation in the treatment of gastrocnemius muscle atrophy after sciatic nerve injury. Methods36 SD rats were randomly divided into the blank group,model group and massage group. In the model group and the massage group,the atrophy of gastrocnemius muscle induced by sciatic nerve injury was established according to reference literature,and the blank group received sham treatment. 7 days after modeling,the massage group was treated with one-finger massage manipulation,and 4 rats were sacrificed when the massage therapy for 10,0 and 30 times respectively. The wet weight of gastrocnemius muscle,the diameter of gastrocnemius muscle cells and the fibrillation potential amplitude of gastrocnemius muscle were measured. After therapy for 30 times,the gastrocnemius muscle of rats in the three groups were stained with HE,and its morphological changes were observed.  Results:After therapy for 30 times,the one-finger massage manipulation could effectively increase the recovery rate of wet weight of gastrocnemius muscle, the difference between the treatment group and model group was statistically significant (P<0.05); the massage manipulation could effectively increase the diameter and cross-section area of the gastrocnemius muscle cells, the differences between the massage group and model group was statistically significant (P<0.05); the massage manipulation of one-finger scrubbing could effectively improve the fibrillation potential amplitude of gastrocnemius muscle, the difference between the massage group and model group was statistically significant (P<0.05). The morphological differences among the three groups were confirmed by HE staining.  Conclusion:The one-finger massage manipulation can effectively relieve the atrophy of gastrocnemius muscle after sciatic nerve injury in rats.