Objective:To observe the clinical efficacy of Shijun Granule on minimal hepatic encephalopathy. Methods76 patients with minimal hepatic encephalopathy were randomly divided into the treatment group and the control group,38 cases in each group. The treatment group was treated orally with Shijun Granule,the control group was treated orally with lactulose syrup (Duphalac),with a course of one month. The related parameters of liver function (ALT, AST),blood ammonia,serum amino acids (aromatic,branched chain amino acid),number-connection test type A ( NCT-A) and digital symbol test(DST)were observed and compared.  Results:① During the trial, totally 5 cases fell off and 71 cases completed the whole test,among which 36 cases in the treatment group and 35 cases in the control group.②Comparison between the treatment group and control group after treatment,the differences on the level of ALT and AST were statistically significant,the indicators decrease in the treatment group were more significant than those in the control group(P<0.05).③Comparison of the treatment before and after within group,the difference on the blood ammonia level in both groups was statistically significant (P<0.05)；comparison of the difference of blood ammonia before and after treatment,the difference between groups was statistically significant,the reduction in treatment group was more obvious than that in the control group(P<0.05).④There were no significant differences on the levels of phenylalanine and tyrosine between the treatment group and control group after treatment (P>0.05).Comparison between groups after treatment,the differences on the levels of leucine,isoleucine,valine were statistically significant (P<0.05),which suggested that the effect of the treatment group on metabolism regulation of branched chain amino acid was more obvious than that of the control group.⑤Comparison between the two groups after treatment,the time of the treatment group in the NCT-A was obviously shorter than that of the control group (P<0.05).The DST score in the treatment group was significantly higher than that in the control group (P<0.05).  Conclusion:Shijun Granule shows good effect in the treatment of minimal hepatic encephalopathy,which is worthy of promotion and application in the early intervention of hepatic encephalopathy.