Objective:To observe the intervention of Babaodan capsule on liver fibrosis induced by dimethylnitrosamine(DMN)in rats. Methods90 Sprague-Dawley male rats were randomly divided into the normal group and modeling group. The rat model of hepatic fibrosis was established by intraperitoneal injection of 0.5 % DMN at the dose of 2 μl/g for 4 weeks. At the end of the fourth week,the rats in the modeling group were randomly divided into the model group,Babaodan capsule groups with high-,medium- and low-dose,Fuzheng Huayu group. Treatment drugs were orally given to the corresponding groups. The normal group and model group were treated with equivalent dose of 0.5% sodium carboxymethyl cellulose (CMC). The treatment course was 4 weeks. At the end of the 8th week,animals were sacrificed and the samples were collected. The serum levels of alanine aminotransferase (ALT),aspartate aminotransferase (AST),albumin (ALB),total bilirubin (TBIL) and the hepatic levels of hydroxyproline (Hyp) were detected. Pathological changes of liver tissue was observed by sirius red staining and HE staining.  Results:Compared with the normal group,the serum levels of ALT, AST and TBIL in the model group were significantly increased (P<0.05),after drug intervention the serum levels of ALT,AST and TBIL were all decreased. HE staining showed that there were a large amount of inflammatory cell infiltration,swelling,degeneration and necrosis,significant bleeding phenomenon in the liver tissue of rats in the model group. Sirius red staining showed that there was obvious hyperplasia of liver collagen with false lobules in the model group. Compared with the normal group,the collagen area and hepatic Hyp content in the model group were significantly increased (P<0.01). After drug intervention,the degree of inflammation and fibrosis in liver tissue were all improved compared with the model group,and the hepatic Hyp content was decreased significantly. The collagen deposition in liver tissue in the Babaodan capsule groups with high- and medium-dose and Fuzheng Huayu group were significantly reduced compared with the model group(P<0.05), and there was no statistically significant difference between the Babaodan capsule group with high-dose and Fuzheng Huayu group.  Conclusion: Babaodan capsule show better reversal effects on rat liver fibrosis induced by DMN. The intervention effects of Babaodan capsule with high-dose on hepatic fibrosis in rats are more prominent compared with the medium-and low-dose,which is similar to the effects of Fuzheng Huayu Capsule as positive control.