Assorted and classified the related literature of syncope syndrome, this paper proposed the new concept of “pain syncope ”(syncope due to pain) and “ depression syncope ”(syncope due to depression syndrome), and mainly discussed the syndrome differentiation and treatment of “ depression syncope ”. It considered that syncope was one of the manifestations of depression syndrome. Person suffered from syncope that caused by the disturbance of qi-movement mediated by the emotional factors,which is called as syncope due to depression syndrome. Syncope due to depression syndrome includes syncope with qi excess,part syncope with blood-inverse and syncope with phlegm disorder. “Zhong e” ,as an important kind of syncope due to depression syndrome,is due to psychasthenia and mainly caused by the temperament endowment as “the internal emotional factors”. Qi adverseness is considered as the basic pathogenesis of syncope due to depression syndrome,which presented the syndrome of syncope with qi disorder and “Zhong e”. Bleeding due to qi reversed flow can be expressed as syncope with blood disorder,phlegm due to qi reversed flow can be expressed as syncope with phlegm disorder. Stagnant blood and phlegm clouding the clear orifices are also the important pathogenesis of syncope due to depression syndrome. Syncope due to depression syndrome show peculiar clinical features,and often accompanied by the manifestations of dominant and recessive depression syndrome. According to the importance and necessity,the therapy point of syncope due to depression syndrome is before syncope,after syncope and syncope in turn. The five treatment principles for syncope due to depression syndrome are soothing liver and regulating qi movement,invigorating heart to tranquilize mind,activating blood and dissolving stasis,removing phlegm and turbid,regulating viscera as well as yin and yang, qi and blood. Syncope due to depression syndrome can be regarded as psychological syncope and vasovagal syncope induced by psychological disorders in modern medicine.