Clinical observation on the effect of “Cupai Decoction” on homocysteine in patients of polycystic ovarian syndrome with insulin resistance

CEN Yi; HONG Qing-xiang; XU Zhu-ting; PAN Cheng

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Clinical observation on the effect of “Cupai Decoction” on homocysteine in patients of polycystic ovarian syndrome with insulin resistance

更新时间：2022-08-31

- Clinical observation on the effect of “Cupai Decoction” on homocysteine in patients of polycystic ovarian syndrome with insulin resistance
- Shanghai Journal of Traditional Chinese Medicine Vol. 50, Issue 10, Pages: 56-59(2016)
- 作者机构：
  
  1. 上海市第八人民医院中医科,上海,200235
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CEN Yi, HONG Qing-xiang, XU Zhu-ting, et al. Clinical observation on the effect of “Cupai Decoction” on homocysteine in patients of polycystic ovarian syndrome with insulin resistance. [J]. Shanghai Journal of Traditional Chinese Medicine 50(10):56-59(2016)
DOI：

CEN Yi, HONG Qing-xiang, XU Zhu-ting, et al. Clinical observation on the effect of “Cupai Decoction” on homocysteine in patients of polycystic ovarian syndrome with insulin resistance. [J]. Shanghai Journal of Traditional Chinese Medicine 50(10):56-59(2016) DOI：

摘要

目的：观察促排汤治疗伴胰岛素抵抗型多囊卵巢综合征的临床疗效及可能机制。方法：将80例多囊卵巢综合征伴胰岛素抵抗患者随机分为治疗组与对照组,每组40例。对照组予炔雌醇环丙孕酮片口服,治疗组予促排汤口服。两组疗程均为3个月、随访3个月,观察临床疗效,比较相关内分泌及性激素指标的变化情况。结果：①试验期间,脱落2例,最终完成试验78例,每组39例。②治疗组、对照组临床总有效率分别为74.36%和51.28%；组间临床疗效比较,差异有统计学意义,治疗组优于对照组(P<0.05)。③治疗前后组内比较,治疗组Hcy水平差异有统计学意义(P<0.05),而对照组差异无统计学意义(P>0.05)。组间治疗后比较,Hcy水平差异有统计学意义,治疗组较对照组明显下降(P<0.05)。随访3个月后,治疗组Hcy水平未见反弹,仍较治疗前及对照组显著下降(P<0.05)。④治疗前后组内比较,治疗组LH、LH/FSH水平,以及对照组LH、T、LH/FSH水平差异有统计学意义(P<0.05)；随访3月后与治疗后组内比较,对照组LH、T、LH/FSH水平明显回弹(P<0.05)。组间同期比较,随访3月后治疗组LH/FSH水平明显低于对照组(P<0.05)。结论：促排汤治疗伴胰岛素抵抗型多囊卵巢综合征的疗效满意,其干预机制可能为有效持续地降低患者Hcy水平,稳定控制LH及LH/FSH水平。

Abstract

Objective:To observe the clinical effect and possible mechanism of “Cupai Decoction” in patients of polycystic ovarian syndrome (PCOS) with insulin resistance (IR). MethodsEighty cases of PCOS with IR were randomly divided into the treatment group and control group, 40 cases in each group. The treatment group was orally treated with “Cupai Decoction”,and the control group was orally treated with Diane-35. Both groups were treated for three months and follow-up for three months. The clinical effect was observed and the index changes in endocrine and sex hormone were compared. Results:①During the trial,two cases among all 80 patients fell off. Finally 78 patients completed the trial,39 cases in each group. ②The total effective rate in the treatment group and control group was 74.36 % and 51.28 %,respectively,the difference was statistically significant and the treatment group was better than the control group(P<0.05). ③Comparison of before and after treatment,the difference on the level of serum homocysteine(Hcy) in the treatment group was statistically significant (P<0.05),but no statistically significant difference in the control group(P>0.05). After treatment,the level of Hcy in the treatment group was obviously decreased compared with the control group,with statistically significant difference (P<0.05). After 3 months follow-up, there was no rebound in the level of Hcy in the treatment group, which was significant decreased compared with treatment before and the control group (P<0.05). ④Comparison of before and after treatment,the differences on the level of LH, LH/FSH in the treatment group and LH,T,LH/FSH in the control group were statistically significant (P<0.05)；After 3 months follow-up, the levels of LH,T,LH/FSH in the control group were rebounded obviously(P<0.05). After 3 months follow-up, the level of LH/FSH in the treatment group was significant lower than that in the control group (P<0.05). Conclusion:Cupai Decoction shows good effect in the treatment of PCOS with IR. Its mechanism may be achieved by reducing the level of Hcy effectively and continuously and controlling the levels of LH, LH/FSH stably.

关键词

多囊卵巢综合征胰岛素抵抗促排汤同型半胱氨酸心血管风险

Keywords

polycystic ovarian syndromeinsulin resistanceCupai Decoctionhomocysteinecardiovascular risk

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