Research progress on the mechanism of tumor apoptosis induced by traditional Chinese medicine

ZHENG Ting-ting; JIAO Li-jing; QUE Zu-jun; WU Jing; XU Ling

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Research progress on the mechanism of tumor apoptosis induced by traditional Chinese medicine

更新时间：2022-08-31

- Research progress on the mechanism of tumor apoptosis induced by traditional Chinese medicine
- Shanghai Journal of Traditional Chinese Medicine Vol. 50, Issue 10, Pages: 103-109(2016)
- 作者机构：
  
  1. 上海中医药大学附属龙华医院肿瘤研究所,上海,200032
- 作者简介：
- 基金信息：
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ZHENG Ting-ting, JIAO Li-jing, QUE Zu-jun, et al. Research progress on the mechanism of tumor apoptosis induced by traditional Chinese medicine. [J]. Shanghai Journal of Traditional Chinese Medicine 50(10):103-109(2016)
DOI：

ZHENG Ting-ting, JIAO Li-jing, QUE Zu-jun, et al. Research progress on the mechanism of tumor apoptosis induced by traditional Chinese medicine. [J]. Shanghai Journal of Traditional Chinese Medicine 50(10):103-109(2016) DOI：

摘要

综述具有影响凋亡相关基因caspase、Bcl-2和survivin表达作用的中药单体、单味中药和中药复方的研究进展。多种中药的单体或单味中药或复方制剂通过影响caspase、Bcl-2和survivin基因的表达而表现出良好的抑制肿瘤增殖、诱导肿瘤凋亡的作用。从中药中筛选具有诱导肿瘤凋亡作用的药物,将是未来抗肿瘤药物研发的重要方向之一。

Abstract

This paper reviewed the research progress on single compounds of Chinese herbs,single Chinese medicinal herb and Chinese herbal compound prescription which affect the expression of apoptosis related genes caspase, Bcl-2 and survivin. Various single compounds of Chinese herbs,single Chinese medicinal herb or Chinese herbal compound prescription show good effect on inhibiting tumor proliferation and inducing tumor apoptosis through the influence on the gene expression of caspase, Bcl-2 and survivin. Screening drugs that with the effect on inducing tumor apoptosis from traditional Chinese medicine, would be one of the important directions for the future research and development of antitumor drugs.

关键词

中药肿瘤凋亡基因caspaseBcl-2survivin

Keywords

traditional Chinese medicinetumorapoptosis genecaspaseBcl-2survivin

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