Clinical observation of Yi Zhi Ping Chan Granule on Parkinson’s disease combined with mild cognitive impairment

YE Qing; ZHANG Hong-zhi; CAI Ding-fang; ZHOU Jie; HE Jing; YUAN Can-xing

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Clinical observation of Yi Zhi Ping Chan Granule on Parkinson’s disease combined with mild cognitive impairment

更新时间：2022-08-31

- Clinical observation of Yi Zhi Ping Chan Granule on Parkinson’s disease combined with mild cognitive impairment
- Shanghai Journal of Traditional Chinese Medicine Vol. 50, Issue 7, Pages: 47-49(2016)
- 作者机构：
  
  1. 上海中医药大学附属曙光医院脑病科,上海,200021
  2. 上海中医药大学附属龙华医院脑病科,上海,200032
- 作者简介：
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YE Qing, ZHANG Hong-zhi, CAI Ding-fang, et al. Clinical observation of Yi Zhi Ping Chan Granule on Parkinson’s disease combined with mild cognitive impairment. [J]. Shanghai Journal of Traditional Chinese Medicine 50(7):47-49(2016)
DOI：

YE Qing, ZHANG Hong-zhi, CAI Ding-fang, et al. Clinical observation of Yi Zhi Ping Chan Granule on Parkinson’s disease combined with mild cognitive impairment. [J]. Shanghai Journal of Traditional Chinese Medicine 50(7):47-49(2016) DOI：

摘要

目的：观察益智平颤方治疗帕金森病合并轻度认知障碍的临床疗效及安全性。方法：将80例患者随机分为治疗组和对照组,每组40例。两组均予西医常规疗法,治疗组同时加服益智平颤方。两组疗程均为3个月,观察帕金森病综合评分量表(UPDRSⅡ、UPDRSⅢ)、日常生活活动量表(ADL)、简易智能量表(MMSE)、蒙特利尔认知评估量表(MOCA)、帕金森神经心理痴呆评定量表(PANDA)的积分变化情况,并采用不良反应量表(TESS)观察不良反应情况。结果：①与本组治疗前比较,治疗组治疗后ADL积分明显减少(P<0.05),对照组治疗后UPDRSⅡ、UPDRSⅢ积分增加(P<0.05)；组间治疗后比较,治疗组UPDRSⅡ、UPDRSⅢ和ADL积分值均明显低于对照组(P<0.05)。②与本组治疗前比较,治疗组治疗后MMSE、MoCA、PANDA积分均明显增加(P<0.05),对照组MoCA积分明显减少(P<0.05)；组间治疗后比较,治疗组各量表积分值均大于对照组(P<0.05)。③治疗组的不良反应发生率为7.5%,明显低于对照组的50.0%,TESS积分值少于对照组(P<0.05)。结论：益智平颤方能明显提高帕金森病合并轻度认知障碍患者的认知水平,改善临床症状及生活质量,且安全性良好。

Abstract

Objective:To observe the clinical efficacy and safety of Yi Zhi Ping Chan Granule on Parkinson’s disease combined with mild cognitive impairment. Methods:Eighty patients with PD-MCI were randomly divided into treatment group and control groups.Each group had forty patients. Both groups were treated with routine western medicine, and the treatment group were given Yi Zhi Ping Chan granule additionally,with a course of 3 month. The score changes of UPDRSⅡ、Ⅲ、 ADL、MMSE、 MOCA、PANDA before and after treatment were observed,as well as the adverse reactions by TESS. Results:① Compared within each group after treatment,the score of ADL decreased significantly in the treatment group(P<0.05),the score of UPDRSⅡ,UPDRSⅢ increased significantly in the control group(P<0.05)；compared with the control group after treatment,the score of ADL,UPDRSⅡ and UPDRSⅢ decreased significantly in the treatment group(P<0.05). ② Compared within each group after treatment,the score of MMSE,MoCA and PANDA increased significantly in the treatment group(P<0.05),the score of MoCA decreased significantly in the control group(P<0.05)；compared with the control group after treatment,these scores increased significantly in the treatment group(P<0.05). The incidence rate of adverse reaction in the treatment group (7.5%) was significantly lower than that in the control group (50%). The score of TESS decreased significantly in the treatment group compared with control group(P<0.05). Conclusion:Yi Zhi Ping Chan granule can significantly and safely improve cognition level of PD-MCI patients,as well as the clinical symptoms and activities of daily living.

关键词

帕金森病轻度认知障碍中西医结合疗法益智平颤方

Keywords

Parkinson’s diseasemild cognitive impairmenttherapy integrated traditional chinese and western medicineYi Zhi Ping Chan granule

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