Objective:To investigate the effects of “Xiaoqinglong Decoction” (XQLD) on the airway remodeling and the expression levels of TGF-β1 and IL-13 in lung tissue of mice with asthmatic airway remodeling. MethodsForty healthy female BABL/c mice were randomly divided into four groups, which consisted of normal control group, asthmatic model group, XQLD group and prednisolone group. The mice were sensitized for 2 weeks and stimulated for 6 weeks by ovalbumin to establish the asthmatic airway remodeling mice model. XQLD group and prednisolone group were given XQLD or prednisolone before each stimulation for 6 weeks. The pathological changes were observed by slicing lung tissues and stained with HE. The thickness of bronchial wall and airway smooth muscle were measured by optical microscope and the Image-Pro Plus 6.0. The expressions of TGF-β1 and IL-13 in lung tissues were observed by immunohistochemistry and detected by Real-time quantitative PCR.  Results:Bronchial wall thickened, inflammatory cell infiltration, smooth muscle hypertrophied and airway remodeled were found in asthmatic model mice. The thickness of bronchial wall and smooth muscle of XQLD group and prednisolone group were less than asthmatic model group. As the result of immunohistochemistry, there were weak expressions of TGF-β1 and IL-13 mainly on bronchial wall in normal control group. Compared with normal control group, the expressions of TGF-β1 and IL-13 were more obvious in asthmatic model group. The gene expressions of TGF-β1 and IL-13 of XQLD group and prednisolone group were significantly lower than asthmatic model group(P<0.05).  Conclusion:The high expressions of TGF-β1 and IL-13 might play an important role in developing airway remodeling of asthma. “Xiaoqinglong Decoction” has some inhibitory effect on airway remodeling in asthmatic mice by inhibiting the expressions of TGF-β1 and IL-13 in lung tissues probably.