Experimental study on modified “Simiao Decoction” in treating uric acid nephropathy in rats

GAO Qiu-jing; XIONG Yan-wen; JIN Zhou-hui

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Experimental study on modified “Simiao Decoction” in treating uric acid nephropathy in rats

更新时间：2022-08-31

- Experimental study on modified “Simiao Decoction” in treating uric acid nephropathy in rats
- Shanghai Journal of Traditional Chinese Medicine Vol. 50, Issue 4, Pages: 70-74(2016)
- 作者机构：
  
  1. 上海市普陀区利群医院中医肾病科,上海,200333
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GAO Qiu-jing, XIONG Yan-wen, JIN Zhou-hui. Experimental study on modified “Simiao Decoction” in treating uric acid nephropathy in rats. [J]. Shanghai Journal of Traditional Chinese Medicine 50(4):70-74(2016)
DOI：

GAO Qiu-jing, XIONG Yan-wen, JIN Zhou-hui. Experimental study on modified “Simiao Decoction” in treating uric acid nephropathy in rats. [J]. Shanghai Journal of Traditional Chinese Medicine 50(4):70-74(2016) DOI：

摘要

目的：探讨加味四妙方对尿酸性肾病大鼠的肾功能、血脂代谢、尿液生化和肾组织病理方面的影响。方法：采用酵母、腺嘌呤制作尿酸性肾病大鼠模型。大鼠随机分为正常组(ZC组)、模型组(MX组)、别嘌醇组(XY组)、加味四妙方组(SMF组),给予相应干预。检测给药后大鼠肾功能,血脂四项,尿液生化和24 h尿蛋白代谢的变化情况；观察肾组织病理改变。结果：①与正常组比较,模型组的BUN、Scr、UA、TC、TG、HDL和LDL 、NAG、β,2,-MG和24 h尿蛋白均有显著的统计学差异(P,<,0.01)。②与模型组比较,加味四妙方组的BUN、Scr、UA、TC、LDL、NAG、β,2,-MG和24 h尿蛋白代谢显著降低(P,<,0.01)；别嘌醇组的UA显著降低(P,<,0.01),而别嘌醇组的Scr、TC、TG、HDL差异无统计学意义(P,>,0.05)。③肾组织病理改变显示,加味四妙方组和别嘌醇组较模型组肾小管内尿酸盐结晶减少,炎性细胞浸润减少,肾小管-间质损伤较轻,其中加味四妙方组损伤最轻,与别嘌醇组比较差异有统计学意义(P,<,0.05)。结论：加味四妙方能够显著改善尿酸性肾病大鼠的肾功能、血脂代谢、尿液生化,减轻肾组织病理损害。

Abstract

Objective:To investigate the effects of modified “Simiao Decoction” on renal function, lipid metabolism, urine biochemistry and renal pathology in rats of uric acid nephropathy. Methods Uric acid nephropathy rats were made with Yeast and Adenine, and then randomized into normal group(ZC group), model group(MX group), allopurinol group(XY group) and treatment group(SMF group), and respectively treated with according therapies. The renal function(BUN, Scr, UA), lipids(TC, TG, HDL, LDL), urine biochemistry(NAG, β,2,-MG, 24-hour urine protein) and renal pathological changes were observed. Results: ①Compared with ZC group, the levels of BUN, Scr, UA, TC, TG, HDL, LDL, NAG, β,2,-MG and 24-hour urine protein were significantly higher in MX group(P,<,0.01). ②Compared with MX group, the levels of BUN, Scr, TC, LDL, NAG, β,2,-MG and 24-hour urine protein were significantly lower in SMF group(P,<,0.01); the level of UA was significantly reduced in XY group(P,<,0.01); while the levels of Scr, TC, TG and HDL was of no significance in XY group(P,>,0.05). ③Renal pathological changes showed that renal tubular urate crystals, inflammatory cell infiltration and tubular interstitial injury were less in SMF group and MX group, with strikingly less lesion in the SMF group than in the MX group(P,<,0.05). Conclusion:s Modified “Simiao Decoction” can improve renal function, lipid metabolism, urine biochemistry and renal pathology in rats of uric acid nephropathy.

关键词

尿酸性肾病高尿酸血症慢性肾脏病加味四妙方大鼠

Keywords

uric acid nephropathyhyperuricemiachronic kidney diseasemodified “Simiao Decoction”rat

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