Objective:To study the effect of “Ye’s renal failure Party A” in the treatment of chronic renal failure. Methods3 and 4 period of 60 cases of patients with chronic kidney disease were selected and randomly divided to control group and treatment group, 30 in each group. The patients in control group were treated with normal western medicine, while the treatment group was added “Ye’s renal failure Party A” on the basis of normal western medicine treatment. After 6 months treatment, we observed two groups of patients with TCM syndrome score, 24 hours urine protein, therapeutic efficacy, renal function, serum TGF beta 1.  Results:①The total effective rate of the treatment group were 93.33% and the control group were 53.33% respectively. The treatment group TCM syndrome score decreased more significantly than the control group (P,<,0.05). ②TCM syndrome score in the treatment group decreased significantly (P,<,0.05), while the score in the control group did not decrease significantly (P,>,0.05) after the treatment. The difference between the groups, TCM syndrome score in the treatment group decreased more significant than the control group (P,<,0.05). ③Compared before and after treatment, the two groups of 24 h urinary protein were significantly decreased (P,<,0.05). Between two groups, 24 h urinary protein in the treatment group decreased more significantly than the control group (P,<,0.05) after the treatment. ④There was no significant difference in UA and BUN in each group before and after treatment (P,>,0.05); Scr in treatment group was significantly decreased (P,<,0.05) and eGFR was significantly increased (P,<,0.05). There were significant differences in Scr and eGFR between the two groups, and the improvement degree of the treatment group was better than the control group (P,<,0.05). ⑤The serum levels of TGF-β,1, were significantly decreased in the treatment group (P,<,0.05), while there was no significant difference in control group (P,>,0.05). Compared between the two groups after the treatment, the difference was statistically significant between the serum levels of TGF-β,1,(P,<,0.05).  Conclusion:“Ye’s renal failure Party A” in the treatment of 3 and 4 chronic kidney disease has obvious curative effect, including reduction proteinuria, improvement renal function and prevention of renal fibrosis.