Clinical study of “Tongbi Paste” for the treatment of diabetic lower limb arteriosclerosis obliterans

SONG Dao-fei; CHEN Feng

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Clinical study of “Tongbi Paste” for the treatment of diabetic lower limb arteriosclerosis obliterans

更新时间：2022-08-31

- Clinical study of “Tongbi Paste” for the treatment of diabetic lower limb arteriosclerosis obliterans
- Shanghai Journal of Traditional Chinese Medicine Vol. 50, Issue 1, Pages: 41-44(2016)
- 作者机构：
  
  1. 湖北中医药大学附属黄石市中医院内分泌科,湖北,黄石,435000
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SONG Dao-fei, CHEN Feng. Clinical study of “Tongbi Paste” for the treatment of diabetic lower limb arteriosclerosis obliterans. [J]. Shanghai Journal of Traditional Chinese Medicine 50(1):41-44(2016)
DOI：

SONG Dao-fei, CHEN Feng. Clinical study of “Tongbi Paste” for the treatment of diabetic lower limb arteriosclerosis obliterans. [J]. Shanghai Journal of Traditional Chinese Medicine 50(1):41-44(2016) DOI：

摘要

目的：观察通痹膏膏方治疗糖尿病下肢动脉硬化闭塞症的临床疗效。方法：将64例糖尿病下肢动脉硬化闭塞症患者随机分为治疗组与对照组,每组32例。对照组予通塞脉片,治疗组予以通痹膏膏方口服。两组疗程均为3个月,观察临床疗效,比较踝肱指数、下肢血管彩超指标、血脂及血浆纤维蛋白原的变化情况。结果：①治疗组、对照组临床总有效率分别为90.63%和68.75%；组间临床疗效比较,差异有统计学意义 (P<0.05)。②治疗前后组内比较,两组踝肱指数差异有统计学意义(P<0.05)；组间治疗前后踝肱指数差值比较,差异有统计学意义(P<0.05)。③治疗前后组内比较,治疗组足背动脉的血管内径、峰值流速、血流量水平差异有统计学意义(P<0.05)；组间治疗后比较,足背动脉的血管内径、峰值流速、血流量水平差异有统计学意义(P<0.05)。④治疗前后组内比较,治疗组TC、TG、LDL-C、HDL-C及FIB水平差异有统计学意义(P<0.05)；组间治疗后比较,TC、TG、LDL-C、HDL-C及FIB水平差异有统计学意义(P<0.05)。结论：通痹膏膏方治疗糖尿病下肢动脉硬化闭塞症疗效满意。

Abstract

Objective:To observe the effects of “Tongbi Paste” on the patients with diabetic lower limb arteriosclerosis obliterans. Methods64 patients with diabetic lower limb arteriosclerosis obliterans were randomly divided into treatment group and control group, 32 in each group. The control group was treated with Tongsaimai Tablet,and the treatment group was treated with “Tongbi Paste”. The courses of the two groups were 3 months. Clinical effects of both treatments were observed, and ankle brachial pressure index, lower lib blood vessel color doppler ultrasound index, blood lipid and plasma albumin changes were compared. Results:①The total clinical efficacy rates of treatment group and control group were 90.63% and 68.75% respectively; there was significant difference in the clinical efficacy between the two groups (P<0.05). ②Compared before and after the treatment, there was significant difference in ankle brachial pressure index in each group(P<0.05). Compared before and after the treatment, there was significant difference in ankle brachial pressure index between the two groups(P<0.05). ③ Compared before and after the treatment, there was significant difference in levels of vessel diameter, peak velocity, and blood flow of dorsalis pedis artery in treatment group(P<0.05). Compared before and after the treatment, there was significant difference in levels of vessel diameter, peak velocity, and blood flow of dorsalis pedis artery between the two groups(P<0.05). ④Compared before and after the treatment, there was significant difference in levels of TC, TG, LDL-C, HDL-C and FIB in treatment group(P<0.05). Compared before and after the treatment, there was significant difference in levels of TC, TG, LDL-C, HDL-C and FIB between the two groups(P<0.05). were power of therapeutic group is 90.6% which is higher than 68.8% of control group(P<0.05). Compared with pre-treatment,ABI,blood flow volume and peak flow velocity of dorsal artery improved significantly at twelve weeks after treatment(P<0.05)；the treatment group had better effects than the control group in reducing blood lipid and fibrinogen(P<0.05). Conclusion:The clinical effect was satisfactory in the treatment of patients with diabetic lower limb arteriosclerosis obliterans with “Tongbi Paste”.

关键词

膏方糖尿病并发症下肢动脉硬化闭塞症益气养阴活血通络

Keywords

herbal pastediabeticperipheral arterial diseaselower limb arteriosclerosis obliteranssupplementing qi and nourishing yinpromoting blood circulation to remove meridian obstruction

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