In view of intercrosses and merges of life science and information science, this paper describes the clinical bottleneck of “Preventive Treatment of Disease” in TCM now days and discusses the solution for it. It is believed that through the comparison of “Preventive Treatment of Disease” and “Treatment of Certain Disease”, introduction of disease risk assessment process in epidemiological modern health management is helpful for reinforcement the clinical application of “Preventive Treatment of Disease” in TCM; through the mixture of “Preventive Treatment of Disease” physique and disease related model which on the combination of disease risk assessment and TCM constitution identification system, we can reveal the clinical essence of “Preventive Treatment of Disease” in TCM, and it is one of the keys for improving clinical efficacy. As a interdisciplinary science solution, big data cloud computing platform, which was built by the combination of big data computing learning electronic physiology of meridians disease risk assessment process and TCM constitution identification system, can lay a foundation for the realization of internet+ TCM “Preventive Treatment of Disease” system.