Objective:To observe the clinical efficacy of “Yiban Decoction” and Losartan for the treatment of chronic nephritis proteinuria. Methods70 patients with chronic nephritis proteinuria were randomly divided into treatment group and control group,35 in each group. Both groups were treated with Losartan, and treatment group was treated with “Yiban Decoction” additionally,with the course of three months for both groups. The clinical efficacy were observed, 24 h urinary protein, plasma protein, TCM syndrome differentiation and renal function related index were compared.  Results:①The total effective rate was 62.86% in the control group and 77.1% in the treatment group, with a difference between the two groups (P<0.05). ②Comparison before and after treatment, there were significant differences in the levels of 24 hour urine protein and plasma protein between the two groups (P<0.05). ③Compared before and after the treatment, there was significant difference in the level of TCM syndrome differentiation in each group(P<0.05). Compared before and after the treatment, there was significant difference in the level of TCM syndrome differentiation between the two groups(P<0.05). ④Compared before and after the treatment, there was significant difference in the level of BUN, Cr, ALB in each group(P<0.05). Compared before and after the treatment, there was significant difference in the level of ALB between the two groups(P<0.05).  Conclusion:“Yiban Decoction” and Losartan for the treatment of Qi Yin deficiency and damp-heat chronic nephritis proteinuria can decrease urinary protein and improve clinical syndrome.