Clinical effect of the treatment of glucocorticoid related osteoporosis with the method of invigorating the kidney and promoting blood circulation combined with western medicine

ZHANG Na; SU Xiao

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Clinical effect of the treatment of glucocorticoid related osteoporosis with the method of invigorating the kidney and promoting blood circulation combined with western medicine

更新时间：2022-08-31

- Clinical effect of the treatment of glucocorticoid related osteoporosis with the method of invigorating the kidney and promoting blood circulation combined with western medicine
- Shanghai Journal of Traditional Chinese Medicine Vol. 50, Issue 1, Pages: 58-61(2016)
- 作者机构：
  
  1. 上海中医药大学附属市中医医院风湿科,上海,200071
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ZHANG Na, SU Xiao. Clinical effect of the treatment of glucocorticoid related osteoporosis with the method of invigorating the kidney and promoting blood circulation combined with western medicine. [J]. Shanghai Journal of Traditional Chinese Medicine 50(1):58-61(2016)
DOI：

ZHANG Na, SU Xiao. Clinical effect of the treatment of glucocorticoid related osteoporosis with the method of invigorating the kidney and promoting blood circulation combined with western medicine. [J]. Shanghai Journal of Traditional Chinese Medicine 50(1):58-61(2016) DOI：

摘要

目的：观察补肾活血方联合西药治疗糖皮质激素相关性骨量丢失的临床疗效。方法：将60例糖皮质激素相关性骨量丢失患者随机分为治疗组和对照组,每组30例。对照组予阿仑磷酸钠VitD,3,片+碳酸钙D,3,片,治疗组在对照组治疗基础上加用补肾活血方。两组疗程均为6个月,观察比较疼痛VAS评分、骨密度及骨代谢相关指标的变化情况。结果：①治疗前后组内比较,两组疼痛VAS评分差异有统计学意义(P,<,0.05)；组间治疗前后疼痛VAS评分差值比较,差异有统计学意义(P,<,0.05)。②治疗前后组内比较,两组腰椎及双髋平均骨密度水平差异均有统计学意义(P,<,0.05)；组间治疗后比较,腰椎及双髋平均骨密度水平差异有统计学意义(P,<,0.05)。③治疗前后组内比较,治疗组BGP、β-CTx、PTH、IL-6水平差异有统计学意义(P,<,0.05),对照组β-CTx、PTH、IL-6水平差异有统计学意义(P,<,0.05)；组间治疗后比较,BGP、β-CTx及IL-6水平差异有统计学意义(P,<,0.05)。结论：补肾活血方联合西药治疗糖皮质激素相关性骨量丢失的疗效满意。

Abstract

Objective:To observe the clinical effect of the treatment of glucocorticoid related osteoporosis with the method of invigorating the kidney and promoting blood circulation combined with western medicine. Methods60 patients with glucocorticoid related osteoporosis were enrolled in the diagnosis,randomly divided into treatment group and control group, 30 in each group. The control group was treated with a lun lin suan naVitD3 tablets plus calcium carbonate tablets, while the treatment group was treated with Chinese medicine of invigorating kidney and promoting blood on the basis of the treatment for the control group. After 6 months of treatment, two groups of visual analog (VAS) pain score, Bone metabolism index, Bone mineral density was observed and liver and kidney function was monitored. Results:① Compared before and after the treatment, there was significant difference in VAS pain score in each group (P<0.05); compared before and after the treatment, there was significant difference in VAS pain score between the two groups (P<0.05). ②Compared before and after the treatment, there was significant difference in Bone metabolism index of lumbar vertebrae and both side of the hip in each group(P<0.05). Compared before and after the treatment, there was significant difference in Bone metabolism index of lumbar vertebrae and both side of the hip between the two groups(P<0.05). ③Compared before and after the treatment, there was significant difference in levels of BGP, β-CTx, PTH and IL-6 in treatment group(P<0.05), while there was significance difference in levels of β-CTx, PTH and IL-6 in control group(P<0.05). Compared before and after the treatment, there was significant difference in levels of BGP, β-CTx and IL-6 between the two groups(P<0.05). Conclusion:The clinical effect was satisfactory in the treatment of glucocorticoid related osteoporosis with the method of invigorating the kidney and promoting blood circulation combined with western medicine.

关键词

糖皮质激素骨量减少骨质疏松补肾活血骨密度骨代谢

Keywords

glucocorticoidosteopeniaosteoporosisinvigorating the kidney and promoting blood circulationbone mineral densitybone metabolism

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