Objective:To discuss bakuchiol on melanin synthesis and its intervention of MAPK signaling transduction pathways in A375 cells. MethodsThe cultured A375 cells were treated with bakuchiol; MTT assay,L-dopa oxidation assay were respectively used to detect the activity of cell and TYR ; odium hydroxide lysis assay were used to detect the change of melanin synthesis ; RT-PCR was applied to measure the mRNA expression levels of TYR,TRP-1,TRP-2 and the mRNA expression levels of JNK2,ERK1,ERK2.  Results:bakuchiol (10-1 μmol/L,10-2 μmol/L,10-3 μmol /L) can inhibit melanin synthesis and the activity of TYR, Bakuchiol(10-1 μmol/L) can significantly reduce the mRNA expression level of TYR, TRP-1,TRP-2,JNK2,ERK1 and ERK2(P<0.05,P<0.01).  Conclusion:Bakuchiol can reduce melanin synthesis and the activity of TYR,and the changes realized probably through reducing the mRNA expression level of TYR,TRP-1,TRP-2,JNK2,ERK1 and ERK2 .