Optimization of extraction process for total triterpenoids in Ligustrum lucidum Ait. by response surface methodology

WU Xiu-hong; SUN Ze; YANG En-long; YU Dan; WU Jun-kai

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Optimization of extraction process for total triterpenoids in Ligustrum lucidum Ait. by response surface methodology

更新时间：2022-08-31

- Optimization of extraction process for total triterpenoids in Ligustrum lucidum Ait. by response surface methodology
- Shanghai Journal of Traditional Chinese Medicine Vol. 50, Issue 1, Pages: 83-87(2016)
- 作者机构：
  
  1. 黑龙江中医药大学中医药研究院,黑龙江,哈尔滨,150040
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WU Xiu-hong, SUN Ze, YANG En-long, et al. Optimization of extraction process for total triterpenoids in Ligustrum lucidum Ait. by response surface methodology. [J]. Shanghai Journal of Traditional Chinese Medicine 50(1):83-87(2016)
DOI：

WU Xiu-hong, SUN Ze, YANG En-long, et al. Optimization of extraction process for total triterpenoids in Ligustrum lucidum Ait. by response surface methodology. [J]. Shanghai Journal of Traditional Chinese Medicine 50(1):83-87(2016) DOI：

摘要

目的：采用星点设计响应面法优选女贞子中总三萜的乙醇回流提取工艺。方法：在单因素考察基础上,利用三因素三水平响应面法研究乙醇浓度、提取时间、溶媒比对女贞子总三萜得率的影响。结果：确定最优提取工艺为12倍量67%乙醇提取2次,每次1.70 h；女贞子总三萜提取量为57.62 mg/g,与预测值的偏差为2.89%。结论：星点设计响应面法优化的女贞子总三萜提取工艺方法简单,精密度高,可预测性较优。

Abstract

Objective:To optimize ethanol reflux extraction process of total triterpenoids in Ligustrum lucidum Ait. MethodsOn the basis of single factor tests,response surface analysis of three-factor-three-level was adopted to investigate effects of ethanol concentration,extracting time and solvent fold on yield of total triterpenoids. Results:Optimal extraction conditions were as follows:extracted 2 times by 12 times the count of 67% ethanol with 1.70 h each time; under these conditions,yield of total triterpenoids was 57.62 mg/g,2.89% in low deviation than predicted. Conclusion:This extraction process of total triterpenoids from L. Lucidum dahurica by central composite design/response surface methodology was a simple method with high precision and good predictability.

关键词

女贞子总三萜响应面法乙醇回流提取法

Keywords

Ligustrum lucidum Ait.total triterpenoidsresponse surface methodologyethanol reflux extraction

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