Not only hypochondriac pain and stomachache, but also cardiodynia,pectoralgia,abdominal pain,osphyalgia,ophthalmalgia,and even pantalgia can all be induced by depression. Apart from the stagnation of liver-qi,and stagnated qi transforming into fire,the pathogenesis of pain can also be connected to the dysfunction of heart,spleen,and kidney which was injured by bad emotion. The severity of pain is related to the activity of heart. Modern medicine proved that pain,psychological factors and pathophysiologic bases are cause-and-effect each other. Pain can be the somatic symptoms of depression. The clinical features of pain due to depression syndrome includes the fluctuation of emotion induced by pain; it possess the characteristics of functionality, variety, universality, relapsing, and peculiarity; it also manifests “the uncertain pain”; and it can be relieved after the antidepressant therapy. The pathogenesis of pain due to depression syndrome includes but not limits to the “pain induced by qi and blood stasis” as well as “pain induced by qi and blood without nourishment”. Treating from the aspect of depression can be considered in the pain treatment.