Objective:To determine effects of “Kangxianling Decoction” (KXLD) on the Akt-mTOR signaling pathway in 5/6 nephrectomized mice renal fibrosis model and discuss mechanism of it  Methods:SPF C57BL/6J male mice were established models of chronic renal failure caused by 5/6 nephrectomized,and two week later after surgery,according to serum creatinine (Scr) level,the mice were divided into model group,KXLD and rapamycin (RAP) group,sham operation group was set at the same time, 10 in each group. KXLD and RAP group were gavaged respectively according to 20 g/kg,RAP 0.8 μg/g,0.5 ml/day. Sham and model groups were administered with the same amount of distilled water. The mice were sacrificed after 8 weeks of treatment,Scr,BUN and 24 h UP were determined, the levels of Akt-mTOR protein and mRNA expression were observed by Western blotting and real-time PCR method  Results:Compared with sham group,the Scr,urea nitrogen,24 h UP and p-Akt,p-mTOR levels increased significantly in the model group (P<0.05, P<0.01). Compared with model group,the Scr,urea nitrogen,24 h UP and p-Akt,p-mTOR protein and Akt,mTORmRNA levels decreased significantly in the KXLD and RAP group (P<0.01, P<0.05). Compared between KXLD and RAP groups,in Scr,24 h UP,KXLD superior to RAP,in mTOR protein and mRNA,RAP superior to KXLD(P<0.05)  Conclusion:“Kangxianling Decoction” is able to protect renal function via Akt-mTOR signaling pathway.