Objective:To explore the efficacy of Schizandra Chinensis polysaccharide (SCP) on dyszoospermia of mice exposed to microwave radiation and its effects on reproductive hormones  Methods:Fifty male BALB /C mice were randomly divided into normal control group,model group,low dose SCP group,middle dose SCP group and high dose SCP group. Except normal control group,the dyszoospermia mouse models were established by exposed to microwave of 1450 MHz frequency,power density of 50 mW/cm,2, for 1 h each day for 12 consecutive days. After modeling,SCP (100,0 and 400 mg/kg) was intragastrically administered at corresponding dose to the low, middle and high dose SCP groups.Equal volume of 0.9%NaCl solution was given to rats in the normal control group and the model group by gastric gavage. All the medication was performed once daily for 30 successive days. The blood serum, testis and epididymis were withdrawal 24 h after the last intragastric administration. The levels of follicle stimulating hormone (FSH),luteinizing hormone (LH),and testosterone (T) in the testis homogenate were determined by enzymelinked immunosorbent assay. The sperm count,the motility rate,and the teratospermia rate were compared. The morphology of the testis was observed using HE staining  Results:Compared with normal control group,the sperm count and the motility rate decreased,the teratospermia rate increased(P,<,0. 01). The serum levels of FSH and LH increased,the T content in the testis homogenate decreased in the model group,showing statistical difference (P,<,0.01). Compared with the model group,the sperm count and the motility rate increased,the teratospermia rate decreased,the serum levels of FSH and LH decreased,the T content in the testis homogenate increased in all SCP groups,showing statistical difference (P,<,0.01 ). All the indices showed dose-dependent manner in the SCP groups. The histologica  Results: showed the pathological injury in the testicular tissue was improved in all SCP groups  Conclusion:SCP showed obvious therapeutical effects on dyszoospermia of mice exposed to microwave radiation,and its mechanisms might be correlate with improving reproductive hormone level and recovering the regulation function of hypothalamus-hypophysis-gonad axis.