Clinical observation of “Yixin Decoction” combined conventional western medicine on the impact of inflammation and oxidative stress in patients with atrial fibrillation

WANG Li-yu; SHEN Yan

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Clinical observation of “Yixin Decoction” combined conventional western medicine on the impact of inflammation and oxidative stress in patients with atrial fibrillation

更新时间：2022-08-31

- Clinical observation of “Yixin Decoction” combined conventional western medicine on the impact of inflammation and oxidative stress in patients with atrial fibrillation
- Shanghai Journal of Traditional Chinese Medicine Vol. 49, Issue 11, Pages: 36-39(2015)
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WANG Li-yu, SHEN Yan. Clinical observation of “Yixin Decoction” combined conventional western medicine on the impact of inflammation and oxidative stress in patients with atrial fibrillation. [J]. Shanghai Journal of Traditional Chinese Medicine 49(11):36-39(2015)
DOI：

WANG Li-yu, SHEN Yan. Clinical observation of “Yixin Decoction” combined conventional western medicine on the impact of inflammation and oxidative stress in patients with atrial fibrillation. [J]. Shanghai Journal of Traditional Chinese Medicine 49(11):36-39(2015) DOI：

摘要

目的：观察益心汤联合常规西药治疗心房颤动(房颤)的临床疗效方法：将72例房颤患者随机分为对照组和治疗组,每组36例。对照组予常规西药治疗,治疗组在对照组治疗措施基础上加用益心汤。两组疗程均为3个月,观察临床疗效与中医证候疗效,比较心脏彩超指标(LAD、LVEF、LVEDD)、炎症指标(Hs-CRP、TNF-α)及氧化应激指标(NOX、SOD)的变化情况结果：①最终完成试验者,治疗组30例,对照组31例。②治疗组、对照组总有效率分别为86.67%和70.97%；组间临床疗效比较,差异无统计学意义(P>0.05)。③治疗组、对照组中医证候总有效率分别为86.67%和60.00%；组间比较,差异有统计学意义(P<0.05)。④组间治疗后比较,LVEDD水平差异有统计学意义,治疗组LVEDD显著减小(P<0.05)。⑤组间治疗后比较,Hs-CRP、TNF-α、NOX、SOD水平差异有统计学意义(P<0.05) 结论：益心汤联合常规西药治疗房颤的疗效满意,其机制可能为通过抑制炎症和氧化应激反应,逆转心房重构。

Abstract

Objective:To observe the clinical efficacy of “Yixin Decoction” combined conventional western medicine to treat Atrial Fibrillation Methods:72 patients diagnosed as atrial fibrillation were randomly divided into the control group and the test group, each group included 36 people. The control group was treated with conventional western medicine, and the test group was treated with Western medicine and “Yixin Decoction”. After three months of treatment, observe the clinical efficacy and compare the changes of Echocardiography, the lever of Hs-CRP, TNF-α, NADPH oxidase and SOD in serum before and after treatment Results:①30 people in the test group and 31 people in the control group completed the study. ②The effective rate of the test group was 86.7%, and the control group was 58.1%, the difference was statistically significant (P<0.05). ③The effective rate of TCM syndrome of the test group was 86.7% and the control group was 60.00%, and the difference between the two groups after treatment was statistically significant(P<0.05). ④The difference of the LVEDD between the two groups after treatment was statistically significant (P<0.05), and the LVEDD of treatment group decreased significantly (P<0.05). ⑤Comparing the two groups after treatment, the difference of the lever of Hs-CRP, TNF-α, NADPH oxidase and SOD was statistically significant (P<0.05) Conclusion:The clinical efficacy of “Yixin Decoction” combined conventional western medicine to treat atrial fibrillation is significant. By reducing the level of inflammation and oxidative stress, “Yixin Decoction” can reverse myocardial remodeling in a certain extent.

关键词

心房颤动益心汤炎症氧化应激心房重构

Keywords

atrial fibrillation“Yixin Decoction”inflammationoxidative stressmyocardial remodeling

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