Objective:To observe the curative effect of “Jiuzi Dihuang Decoction” on primary desiccation syndrome patients  Methods:60 diagnosed primary desiccation syndrome patients were divided randomly into treatment group and control group, 30 in each group. The patients of control group were administered with Hydroxychloroquine Sulfate Tablets, while the treatment group with “Jiuzi Dihuang Decoction”. Two groups were treated for 3 months. The changes of the clinical symptom scores, the length of Schirmer test and tear cytokine levels were observed  Results:①Within group comparison before and after the treatment, the differences of the clinical symptom scores were statistically significant in both two groups (P,<,0.05); Compared in each group, the difference of the clinical symptom scores before and after the treatment was statistically significant (P,<,0.05). ②Within group comparison before and after the treatment, the differences of the length of Schirmer test were statistically significant in both two groups (P,<,0.05); Compared in each group, the difference of the length of Schirmer test between before and after the treatment was statistically significant (P,<,0.05). ③Tear cytokine IL-2,IL-4,IL-10 could not be detected before and after the treatment. Within group comparison before and after the treatment, the differences of the positive rate of INF-γ and IL-6 were statistically significant in both two groups (P,<,0.05); Between group comparison of the differences of the positive rate of INF-γ and IL-6 between before and after the treatment, the differences were statistically significant (P,<,0.05)  Conclusion:“Jiuzi Dihuang Decoction” can both relieve clinical symptoms and increase lacrimal secretion. The mechanism may be modulating the immune system and reducing inflammation by depressing expression of CD4,+,T cell.