The influence of “Shenkang Injection” on oxidative stress and inflammatory factors in elderly maintenance hemodialysis patients

ZHOU Jun; WANG Jun; LI Yi

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The influence of “Shenkang Injection” on oxidative stress and inflammatory factors in elderly maintenance hemodialysis patients

更新时间：2022-08-31

- The influence of “Shenkang Injection” on oxidative stress and inflammatory factors in elderly maintenance hemodialysis patients
- Shanghai Journal of Traditional Chinese Medicine Vol. 49, Issue 10, Pages: 46-48(2015)
- 作者机构：
  
  1. 新疆生产建设兵团医院,新疆,乌鲁木齐,830000
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ZHOU Jun, WANG Jun, LI Yi. The influence of “Shenkang Injection” on oxidative stress and inflammatory factors in elderly maintenance hemodialysis patients. [J]. Shanghai Journal of Traditional Chinese Medicine 49(10):46-48(2015)
DOI：

ZHOU Jun, WANG Jun, LI Yi. The influence of “Shenkang Injection” on oxidative stress and inflammatory factors in elderly maintenance hemodialysis patients. [J]. Shanghai Journal of Traditional Chinese Medicine 49(10):46-48(2015) DOI：

摘要

目的：探讨肾康注射液对维持性血液透析老年患者氧化应激及炎性因子水平的影响方法：将88例肾衰竭维持性血液透析老年患者随机分为两组,每组44例；在常规治疗基础上,对照组维持血液透析,观察组同时结合肾康注射液静脉滴注治疗,疗程4周。检测两组治疗前后患者肾功能、氧化应激及炎性因子各项指标变化情况结果：①肾功能:治疗后观察组Scr、BUN、Ccr较治疗前显著改善(P<0.05),且其改善优于对照组(P<0.05)；②应激反应指标:治疗后观察组MDA、SOD、T-AOC、GSH-Px较治疗前明显改善(P<0.05),且其改善优于对照组(P<0.05)；③炎性因子:治疗后观察组炎性因子CRP、IL-6、IL-8、TNF-α水平较治疗前均明显降低(P<0.05),且观察组炎性因子水平均低于对照组(P<0.05) 结论：肾康注射液可改善维持性血液透析老年患者肾功能、氧化应激及炎症状态。

Abstract

Objective:To explore the influence of renal function, oxidative stress and inflammatory cytokines on old maintenance hemodialysis patients treated by “Shenkang Injection” Methods:88 elderly cases of maintenance hemodialysis patients were randomly divided into two groups equally. On the basis of conventional treatment, cases in control group were given pure blood dialysis, while patients in treatment group were treated by “Shenkang Injection”, and the course was 4 weeks. The patients’ renal function, oxidative stress and inflammatory factor indicators were tested and compared Results:①The levels of renal function indexes SCr, BUN, Ccr in treatment group after treatment were significantly improved than before treatment, and the difference of two groups had statistical significance (P<0.05); ②The levels of stress reaction index MDA, SOD, T-AOC, GSH-Px in treatment group after treatment were significantly improved than before treatment, these differences were statistically significant (P<0.05); ③The levels of inflammatory factor CRP, IL-6, IL-8, TNF-α in treatment group after treatment were significantly reduced than before treatment and these differences were statistically significant (P<0.05) Conclusion:“Shenkang Injection” can improve elderly maintenance hemodialysis patients with renal function, oxidative stress and inflammation.

关键词

终末期肾病维持性血液透析肾康注射液肾功能氧化应激炎性因子

Keywords

ESRDhemodialysis“Shenkang Injection”renal functionoxidative stressinflammatory factors

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