Clinical observation on curative effect of treating brain metastasis from lung cancer patients by “Sanjie Tongluo Decoction” and radiotherapy

XIANG Lian-lian; LI Wei; ZHANG Wei; XU Zu-hong; WANG Zhong-qi

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Clinical observation on curative effect of treating brain metastasis from lung cancer patients by “Sanjie Tongluo Decoction” and radiotherapy

更新时间：2022-08-31

- Clinical observation on curative effect of treating brain metastasis from lung cancer patients by “Sanjie Tongluo Decoction” and radiotherapy
- Shanghai Journal of Traditional Chinese Medicine Vol. 49, Issue 9, Pages: 37-39(2015)
- 作者机构：
  
  1. 上海中医药大学附属龙华医院肿瘤二科,上海,200032
- 作者简介：
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XIANG Lian-lian, LI Wei, ZHANG Wei, et al. Clinical observation on curative effect of treating brain metastasis from lung cancer patients by “Sanjie Tongluo Decoction” and radiotherapy. [J]. Shanghai Journal of Traditional Chinese Medicine 49(9):37-39(2015)
DOI：

XIANG Lian-lian, LI Wei, ZHANG Wei, et al. Clinical observation on curative effect of treating brain metastasis from lung cancer patients by “Sanjie Tongluo Decoction” and radiotherapy. [J]. Shanghai Journal of Traditional Chinese Medicine 49(9):37-39(2015) DOI：

摘要

目的：观察散结通络方联合放疗治疗肺癌脑转移的临床疗效方法：将76例肺癌脑转移患者随机分为治疗组与对照组,每组38例。治疗组放疗后予散结通络方口服,对照组予单纯放疗及对症治疗。两组疗程均为6个月,观察临床疗效及无进展生存期(PFS),比较肿瘤标志物水平(CEA、CA50、CA199、CA125)及免疫功能指标(NK、CD3,+,、CD4,+,、CD8,+,、CD4,+,/CD8,+,)的变化情况结果：①治疗组、对照组临床总有效率分别为94.74%和89.47%；组间临床疗效比较,差异无统计学意义(P,>,0.05)。②疗程期间,治疗组、对照组中位PFS分别为5.67个月和3.29个月,组间中位PFS比较差异有统计学意义(P,<,0.05)。③组间治疗后比较,CEA、CA50、CA125水平差异有统计学意义,治疗组低于对照组(P,<,0.05)。④组间治疗后比较,NK水平差异有统计学意义,治疗组高于对照组(P,<,0.05) 结论：散结通络方联合放疗治疗肺癌脑转移,可显著抑制脑转移瘤生长,延长无进展生存期,改善患者免疫功能。

Abstract

Objective:To observe the clinical curative effects of “Sanjie Tongluo Decoction” combined with radiotherapy on brain metastasis tumor from lung cancer Methods:76 patients with brain metastasis tumor from lung cancer were equally randomized to the therapy group and the control group. The patients in the therapy group were provided “Sanjie Tongluo Decoction” after radiotherapy, while the patients in the control group were provided radiotherapy and symptomatic treatment, which follow-up 6 months. The efficacy of the solid tumor, progress free survival, tumor markers and immune functions were evaluated between the two groups Results:① The evaluating effective rate was 94.74% and 89.47% respectively in the therapy group and the control group; There was no significant difference in clinical efficacy between the two groups (P>0.05). ② The progression free survival of brain metastases median was 5.67 months and 3.29 months respectively in the therapy group and the control group; There was significant difference in PFS in between the two groups (P<0.05). ③ Compared between the two groups after the treatment, the serum levels of CEA, CA50 and CA125 were significantly lower in the therapy group than in the control group(P<0.05). ④ Compared between the two groups after the treatment, the NK levels were significantly higher in the therapy group than in the control group(P<0.05) Conclusion:“Sanjie Tongluo Decoction” can inhibit tumor growth of brain metastases after radiotherapy, and can prolong the progression free survival, as well as can improve the immune functions of the patients.

关键词

肺癌脑转移散结通络方放射治疗无进展生存期

Keywords

lung cancerbrain metastasis“Sanjie Tongluo Decoction”radiotherapyprogression free survival

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