Clinical observation of “Baogen-Ⅰ Decoction” in treating repeated respiratory tract infection of lung-spleen deficiency in 60 children

DING Hui-ling; CHE Da-dian

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Clinical observation of “Baogen-Ⅰ Decoction” in treating repeated respiratory tract infection of lung-spleen deficiency in 60 children

更新时间：2022-08-31

- Clinical observation of “Baogen-Ⅰ Decoction” in treating repeated respiratory tract infection of lung-spleen deficiency in 60 children
- Shanghai Journal of Traditional Chinese Medicine Vol. 49, Issue 9, Pages: 43-45(2015)
- 作者机构：
  
  1. 上海市儿童医院,上海交通大学附属儿童医院中医科,上海,200040
- 作者简介：
- 基金信息：
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DING Hui-ling, CHE Da-dian. Clinical observation of “Baogen-Ⅰ Decoction” in treating repeated respiratory tract infection of lung-spleen deficiency in 60 children. [J]. Shanghai Journal of Traditional Chinese Medicine 49(9):43-45(2015)
DOI：

DING Hui-ling, CHE Da-dian. Clinical observation of “Baogen-Ⅰ Decoction” in treating repeated respiratory tract infection of lung-spleen deficiency in 60 children. [J]. Shanghai Journal of Traditional Chinese Medicine 49(9):43-45(2015) DOI：

摘要

目的：观察“宝根1号”方治疗肺脾两虚型小儿反复呼吸道感染(RRTI)的临床疗效及其作用机制方法：将120例肺脾两虚型RRTI患儿随机分为治疗组和对照组(每组60例),分别给予“宝根1号”方和匹多莫德口服液治疗,疗程8周。观察两组临床疗效、治疗前后免疫球蛋白和T细胞亚群的变化结果：治疗组总有效率为91.67%,对照组为66.67%；治疗组疗效优于对照组(P,<,0.01)。治疗后,两组IgG、IgA、IgM含量较治疗前有所增加(P,<,0.05,P,<,0.01),治疗组IgG、IgA、IgM含量高于对照组(P,<,0.01)；治疗组CD3,+,、CD4,+,、CD8,+,较治疗前明显升高(P,<,0.01),治疗组CD3,+,、CD4,+,明显高于对照组(P,<,0.01) 结论：“宝根1号”方能改善RRTI患儿体液免疫和细胞免疫,治疗肺脾两虚型RRTI疗效良好。

Abstract

Objective:To investigate the clinical therapeutic effect and function mechanism of “Baogen-Ⅰ Decoction ” on Repeated Respiratory Tract Infection(RRTI)(deficiency of both lung and spleen, DBLP) Methods:120 children with RRTI were assigned (DBLP) randomly into two groups, the test group treated with “Baogen-Ⅰ Decoction ” and the control group treated with Pidotimod Solution, and the course of the treatment was 8 weeks. The clinical efficacy and the cell group changes of T-cell subsets and immunoglobulin before and after treatment were observed Results:The effective rate of test group and control group were 91.67% and 66.67% respectively. The clinical therapeutic effect of test group was better than that of control group(P,<,0.01). After the treatment, IgG, IgA and IgM level increased than that before the treatment in both groups(P,<,0.05,P,<,0.01). IgG, IgA and IgM level increased more significantly in test group than the control one(P,<,0.01) ; the level of CD3,+, CD4,+and, CD8,+, of the test group after the treatment increased than that before the treatment, and the level of CD3,+, and CD4,+, increased more significantly in test group than the control group (P,<,0.01) Conclusion:“Baogen-Ⅰ Decoction” could well regulate the humoral immunity and cellular immunity of children with RRTI and has a better clinical efficacy in children RRTI (DBLP).

关键词

“宝根1号”小儿反复呼吸道感染免疫球蛋白T细胞亚群

Keywords

“Baogen-Ⅰ Decoction ”Repeated Respiratory Tract Infection(RRTI)immunoglobulinT-cell subsets

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