Influence of modified “Shengjiang Powder” on inflammatory cytokines in patients with pulmonary infection and sepsis of toxin-heat excess

GUO Jian; QIAN Feng-hua; ZHAO Lei; WU Xiao-yang; SUN Fang-yuan; QIAN Yi-ming

您当前的位置：

首页 >

文章列表页 >

Influence of modified “Shengjiang Powder” on inflammatory cytokines in patients with pulmonary infection and sepsis of toxin-heat excess

更新时间：2022-08-31

- Influence of modified “Shengjiang Powder” on inflammatory cytokines in patients with pulmonary infection and sepsis of toxin-heat excess
- Shanghai Journal of Traditional Chinese Medicine Vol. 49, Issue 7, Pages: 38-40(2015)
- 作者机构：
  
  1. 上海中医药大学附属岳阳中西医结合医院急诊医学科,上海,200437
- 作者简介：
- 基金信息：
- DOI：
  CLC：
扫描看全文
GUO Jian, QIAN Feng-hua, ZHAO Lei, et al. Influence of modified “Shengjiang Powder” on inflammatory cytokines in patients with pulmonary infection and sepsis of toxin-heat excess. [J]. Shanghai Journal of Traditional Chinese Medicine 49(7):38-40(2015)
DOI：

GUO Jian, QIAN Feng-hua, ZHAO Lei, et al. Influence of modified “Shengjiang Powder” on inflammatory cytokines in patients with pulmonary infection and sepsis of toxin-heat excess. [J]. Shanghai Journal of Traditional Chinese Medicine 49(7):38-40(2015) DOI：

摘要

目的：观察升降散加味治疗肺部感染合并脓毒症的临床疗效及其作用机制方法：将50例肺部感染合并脓毒症患者随机分为对照组和治疗组,每组25例；对照组给予西医常规治疗,治疗组在西医常规治疗基础上加用升降散加味,疗程7天。观察两组治疗前后中医证候积分、急性生理学及慢性健康状况(APACHEⅡ)评分、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)变化情况结果：治疗后两组中医证候积分均较治疗前降低(P<0.05),且治疗组低于对照组(P<0.05)；治疗后两组患者APACHEⅡ评分、CRP、TNF-α、IL-6水平均降低(P<0.05),且治疗组低于对照组(P<0.05) 结论：升降散加味治疗肺部感染合并脓毒症的主要机制是降低炎症因子以减轻炎症反应。

Abstract

Objective:To observe the clinical efficacy of modified “Shengjiang Powder” in the treatment of pulmonary infection combined with sepsis of toxin-heat excess Methods:Fifty subjects were randomized into two groups:control group in which 25 cases were treated with routine modality and treatment group in which 25 cases were treated with routine modality and modified “Shengjiang Powder”, with a course of 7 days. The symptom scores, APACHEⅡ score, CRP, TNF-α and IL-6 were evaluated before and after treatment Results:After treatment, the symptom scores were reduced in both groups(P<0.05), with lower score in the treatment group than in the control group(P<0.05); the APACHEⅡ scores and the levels of CRP, TNF-α and IL-6 were decreased in both groups(P<0.05), with more significant decrease in the treatment group than in the control group(P<0.05) Conclusion:Modified “Shengjiang Powder” is effective for pulmonary infection combined with sepsis of toxin-heat excess by reduce the levels of inflammatory cytokines to depress inflammation.

关键词

脓毒症肺部感染升降散加味炎症因子

Keywords

sepsispulmonary infectionmodified “Shengjiang Powder”inflammatory cytokine

references

Views

223

下载量

CSCD

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Discussion on treatment of hematogenous sepsis based on syndrome differentiation of six channels theory

Clinical study on the treatment of gastrointestinal dysfunction of spleen yang deficiency type sepsis by acupoint application of cinnamon powder combined with conventional western medicine therapy

Effects of Radix et Rhizoma Rhei and Radix Salviae Miltiorrhizae on levels of serum inflammatory factors in septic rats by miRNA-155

Correlation between collateral structure abnormality and pathological mechanism of sepsis

Effects of Shengjiang Powder on lipopolysaccharide induced myocardial injury in septic rats via TLR-4/NF-κB signaling pathway

Related Author

No data

Related Institution

Guangdong Provincial Hospital of Traditional Chinese Medicine

College of Nursing, Hunan University of Traditional Chinese Medicine

Department of Critical Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine

Southern Hospital of Southern Medical University

Department of Critical Care Medicine, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

⁰