Clinical observation on the efficacy of the traditional Chinese medicine “Wubai Decoction” combined with fluconazole on oral candidiasis

YANG Jing-jing; ZHOU Zeng-tong; ZHOU Hai-wen; FAN Yuan; SHEN Xue-min

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Clinical observation on the efficacy of the traditional Chinese medicine “Wubai Decoction” combined with fluconazole on oral candidiasis

更新时间：2022-08-31

- Clinical observation on the efficacy of the traditional Chinese medicine “Wubai Decoction” combined with fluconazole on oral candidiasis
- Shanghai Journal of Traditional Chinese Medicine Vol. 49, Issue 7, Pages: 53-55(2015)
- 作者机构：
  
  1. 南京医科大学口腔疾病研究江苏省重点实验室,江苏,南京,210029
  2. 南京医科大学附属口腔医院牙体牙髓黏膜科,江苏,南京,210029
  3. 上海交通大学医学院附属第九人民医院口腔黏膜科,上海,200011
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YANG Jing-jing, ZHOU Zeng-tong, ZHOU Hai-wen, et al. Clinical observation on the efficacy of the traditional Chinese medicine “Wubai Decoction” combined with fluconazole on oral candidiasis. [J]. Shanghai Journal of Traditional Chinese Medicine 49(7):53-55(2015)
DOI：

YANG Jing-jing, ZHOU Zeng-tong, ZHOU Hai-wen, et al. Clinical observation on the efficacy of the traditional Chinese medicine “Wubai Decoction” combined with fluconazole on oral candidiasis. [J]. Shanghai Journal of Traditional Chinese Medicine 49(7):53-55(2015) DOI：

摘要

目的：观察中药五白方漱口联合氟康唑治疗口腔念珠菌病的临床疗效方法：将105例口腔念珠菌病患者随机分成A组、B组与C组,每组35例。A组单用五白方漱口,B组予0.9%NaCl溶液漱口加氟康唑口服,C组予五白方漱口加氟康唑口服。各组疗程均为14天,观察临床疗效及安全性,比较真菌转阴率情况结果：①最终完成试验者94例,其中A组35例,B组32例,C组27例。②A组、B组、C组总有效率分别为68.57%、50.00%和85.19%；组间临床疗效比较,C组分别优于A组与B组(P<0.05)。③A组、B组、C组真菌转阴率分别为40.00%、40.63%和66.67%；组间转阴率比较,C组分别低于A组与B组(P<0.05)。④各组均未出现不良反应结论：中药五白方漱口联合氟康唑治疗口腔念珠菌病的疗效较佳,可显著抑菌。

Abstract

Objective:To evaluate the efficacy of the traditional Chinese medicine “Wubai Decoction” combined with fluconazole on oral candidiasis Methods:105 cases of oral candidiasis patients were randomly divided into group A (“Wubai Decoction” mouth rinse group) and B (0.9% sodium chloride mouth rinse combined with fluconazole) and C (“Wubai Decoction” mouth rinse combined with fluconazole), 35 cases in each group. Clinical curative effect, drug safety and the negative rate of Candida albicans were evaluated in all 14 days Results:①Finally 94 cases were completed, among which 35 cases in group A, 32 cases in B group and 27 cases in group C. ②Total effective rate of the treatment of group A , B and C were 68.57%, 50.00% and 85.19% respectively. Clinical curative effect comparison between groups, group C was better than group A and B (P<0.05). ③The negative rate of Candida albicans in group A, B and C were 40.00%, 40.63% and 66.67% respectively, and group C was the best in 3 groups (P<0.05). ④Adverse drug reactions were not found in 3 groups Conclusion:“Wubai Decoction” mouth rinse combined with fluconazole for oral candidiasis can achieve satisfactor Results:.

关键词

口腔念珠菌病五白方氟康唑真菌感染中西医结合疗法

Keywords

oral candidiasis“Wubai Decoction”fluconazolefungal infectionintegrated traditional Chinese and Western medicine therapy

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