Objective:To establish an evaluation method of efficacy on monitoring pulsatile perfusion during cardiopulmonary bypass (CPB)based on “Cunkou” sphygmogram test through monitoring effects of different types of pulsatile perfusion on body during cardiopulmonary bypass  Methods:52 patients with heart valve diseases undergoing cardiopulmonary bypass were randomized into pulsatile group(P group,n=26) and nonpulsatile group(NP group,n=26). The “Cunkou” pulse wave,pump flow rate,arterial pressure and pump pressure were recorded by PowerLab 8/30 physiology recorder. The value of pulse pressure(ΔP),mean arterial pressure(MAP),energy equivalent pressure(EEP) and surplus hemodynamic energy(SHE) were calculated during CPB stabled. Thrombelastograph analyzer(TEG)was examined  Results:① The “Cunkou” pulse waveforms could be detected in all patients before CPB. After the CPB, the “Cunkou”pulse waveforms could be detected in P group but could not be detected in NP group. ② The ΔP,EEP and SHE were significantly higher in P group than NP group(P<0.001),and the MAP was no significant difference in both groups(P>0.05). ③ The R level amplified longer in P group than NP group(P<0.05)and CI level cut shorter in TEG in P group than in NP group(P<0.05)  Conclusion:Pulsatile perfusion during cardiopulmonary bypass was better than nonpulsatile in such aspects as increasing blood perfusion pressure, increasing blood perfusion energy and decreasing blood viscosity, etc. The ΔP,EEP and SHE were significantly higher in pulsatile perfusion during cardiopulmonary bypass than nonpulsatile. It suggested that sphygmogram can be used as an   Objective: index on monitoring pulsatile perfusion during cardiopulmonary bypass.