Objective:This paper is to investigate the anti-depression effect of classic recipe “Ganmai Dazao Decoction” by observing the change of behavior characteristics in depressed rats  Methods:40 Wistar male rats were randomly divided into control group,model group,“Ganmai Dazao Decoction” group and fluoxetine group,10 in each group. The models were established by chronic unpredictable stress combined solitary keeping 28 days and were given 28 days of drug intervention after modeling success. They were carried by open field test and sugar consumption test to observe the behavior change of depressed rats. The experimental data was recorded and statistical analysis  Results:Compared with normal control group,Ganmai Dazao Decoction group and fluoxetine group,weight,horizontal movement distance, upright time and the consumption of sugar water in model group, Ganmai Dazao Decoction group and fluoxetine group showed a tendency to decrease significantly(P<0.05). After the 56th day of the test, weight, horizontal movement distance and the consumption of sugar water increased in the Ganmai Dazao Decoction group(P<0.05), while the fluoxetine group were increased than the model group(P<0.05). Compare between the Ganmai Dazao Decoction group and the fluoxetine group,no significant difference was found in the above index(P>0.05)  Conclusion:“Ganmai Dazao Decoction” can affect behavioral characteristics in rat model of depression and relieve the depressed-like behavior in depressed rats.