Objective:The current research is to observe the contents change of IL-4,IFN-γ,IL-17 and IL-10 in allergic rhinitis rats’ serum,analyze the regulating role of Bimingan Prescription in the cytokines and the possible mechanism of its treatment of allergic rhinitis  Methods:32 SD rats are randomly divided into blank group, model group, Bimingan group and Loratadine group. Apart from the blank group,other groups established AR rats model with OVA. When the model was established, fed the objects with normal saline, water extrat of Bimingan Prescription and Loratadine water solution. Observe the scores of rats symptoms for 7 days, 14 days and 28 days after afterwards. Detect cytokine of IL-4, IFN-γ, IL-17 and IL-10 with ELISA after the 28 days afterwards  Results:7 days, 14days and 28 days after the administration, nasal symptoms of Bimingan group and Loratadine group have been more obviously relieved than the model group(P<0.01). After the model was established,the contents of IL-4 and IL-17 of model group obviously increased and the IFN-γ and IL-10 decreased(P<0.01). Compared with model group, the contents of IL-4 and IL-17 of Bimingan group and Loratadine group decreased and IFN-γ and IL-10 increased.(P<0.01)  Conclusion:It showed that Bimingan Prescription was effective on treating allergic rhinitis. One of the possible mechanism of Bimingan Presciption treating allergic rhinitis was regulating the cell function balance between Th1/Th2 and Th17/Treg through influencing the contents of IL-4, IFN-γ, IL-17 and IL-10.