Correlative studies of content of hesperidin, limonin and nomilin in different parts of citrus with their antioxidant and anti-breast cancer cell activities

LI Yun; XING Li-na; ZHOU Ming-mei; PEI Jin; LUO Jing

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Correlative studies of content of hesperidin, limonin and nomilin in different parts of citrus with their antioxidant and anti-breast cancer cell activities

更新时间：2022-08-31

- Correlative studies of content of hesperidin, limonin and nomilin in different parts of citrus with their antioxidant and anti-breast cancer cell activities
- Shanghai Journal of Traditional Chinese Medicine Vol. 49, Issue 6, Pages: 87-90(2015)
- 作者机构：
  
  1. 上海中医药大学中医方证与系统生物学研究中心,上海,201203
  2. 成都中医药大学药学院中药资源教研室,四川,成都,610075
- 作者简介：
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LI Yun, XING Li-na, ZHOU Ming-mei, et al. Correlative studies of content of hesperidin, limonin and nomilin in different parts of citrus with their antioxidant and anti-breast cancer cell activities. [J]. Shanghai Journal of Traditional Chinese Medicine 49(6):87-90(2015)
DOI：

LI Yun, XING Li-na, ZHOU Ming-mei, et al. Correlative studies of content of hesperidin, limonin and nomilin in different parts of citrus with their antioxidant and anti-breast cancer cell activities. [J]. Shanghai Journal of Traditional Chinese Medicine 49(6):87-90(2015) DOI：

摘要

目的：考察柑橘不同用药部位——橘核、橘络和陈皮中橙皮苷、柠檬苦素及诺米林的含量与其抗氧化和抗乳腺癌活性的相关性方法：通过HPLC法检测来自不同产地的橘核、橘络和陈皮药材中橙皮苷、柠檬苦素及诺米林的含量,结合体外DPPH和FRAP抗氧化实验方法以及MTT法研究3种成分的含量差异对药材抗氧化活性和抑制乳腺癌细胞MCF-7增殖作用的影响结果：橙皮苷含量:陈皮>橘络>橘核；柠檬苦素类物质含量:橘核>橘络>陈皮；体外抗氧化活性:陈皮>橘络>橘核；抑制乳腺癌细胞增殖作用:橘核>橘络>陈皮结论：橘核、橘络和陈皮的抗氧化活性强弱主要与橙皮苷含量相关,而三者的抗乳腺癌活性强弱主要与其柠檬苦素和诺米林含量相关。

Abstract

Objective:This paper is to study the correlation of contents of hesperidin,limonin and nomilin from different parts of citrus with their antioxidant and anti-breast cancer cell activities Methods:The contents of hesperidin,limonin and nomilin in different parts of citrus,tangerine seed,pith and peel were detected with HPLC method. Furthermore,the in vitro antioxidant effects of the three parts of tangerine were studied with DPPH and FRA Methods:,and anti-breast cancer cell (MCF-7) activities were studied with MTT assay Results:The tangerine peel has the highest content of hesperidin,while the tangerine seed contains the highest content of limonoids. Relevant to the content study,tangerine peel has the stronger antioxidant activities in vitro than the other two,while the tangerine seed show more stronger anti-breast cancer cell activities Conclusion:The antioxidant activites of tangerine seed,pith and peel are mainly correlated with their contents of hesperidin,and the anti-breast cancer cell activities are correlated with their contents of limonins.

关键词

橘核橘络陈皮橙皮苷柠檬苦素诺米林抗氧化抗乳腺癌细胞活性

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School of Pharmaceutical Sciences, Shandong University, Ji’nan

Ji’nan Central Hospital Affiliated to Shandong University, Ji’nan

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