Combination of “Yiqi Huaju Granules” and western medicine for the treatment of metabolic syndrome coupled with microalbuminuria:a random, double-blind, placebo trial

WANG Tian-zhan; HUO Qing-ping; FU Xiao-dong; HE Yan-ming; WANG Wen-jian

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Combination of “Yiqi Huaju Granules” and western medicine for the treatment of metabolic syndrome coupled with microalbuminuria:a random, double-blind, placebo trial

更新时间：2022-08-31

- Combination of “Yiqi Huaju Granules” and western medicine for the treatment of metabolic syndrome coupled with microalbuminuria:a random, double-blind, placebo trial
- Shanghai Journal of Traditional Chinese Medicine Vol. 49, Issue 5, Pages: 36-40(2015)
- 作者机构：
  
  1. 上海交通大学附属第六人民医院中医科,上海,200233
  2. 复旦大学附属华山医院中西医结合科,上海,200040
  3. 上海中医药大学附属岳阳中西医结合医院内分泌科,上海,200437
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WANG Tian-zhan, HUO Qing-ping, FU Xiao-dong, et al. Combination of “Yiqi Huaju Granules” and western medicine for the treatment of metabolic syndrome coupled with microalbuminuria:a random, double-blind, placebo trial. [J]. Shanghai Journal of Traditional Chinese Medicine 49(5):36-40(2015)
DOI：

WANG Tian-zhan, HUO Qing-ping, FU Xiao-dong, et al. Combination of “Yiqi Huaju Granules” and western medicine for the treatment of metabolic syndrome coupled with microalbuminuria:a random, double-blind, placebo trial. [J]. Shanghai Journal of Traditional Chinese Medicine 49(5):36-40(2015) DOI：

摘要

目的：观察益气化聚颗粒联合西药治疗代谢综合征微量白蛋白尿的临床疗效方法：将100例代谢综合征微量白蛋白尿症患者随机分为治疗组与对照组,每组50例。治疗组在常规西医治疗基础上加用益气化聚颗粒,对照组在常规西医治疗基础上加用安慰剂。两组疗程均为12周,观察微量白蛋白尿的转阴率,比较尿液相关指标(MA、UACR、24 hTP、尿转铁蛋白及尿β,2,微球蛋白)、形体体征指标(BMI、WHR、SBP、DBP及MAP)、血糖(FPG、2 hPPG、HbA1c及HOMA-IR)及血脂(TC、TG、LDL、HDL)的变化情况结果： ①试验期间无脱落病例,100例受试者均完成试验研究。②治疗组、对照组转阴率分别为28.00%和10.00%；组间转阴率比较,差异有统计学意义(P,<,0.05)。③组间治疗后比较,MA、UACR、24 hTP及尿β,2,微球蛋白水平差异有统计学意义(P,<,0.05)。④组间治疗后比较,BMI、WHR、SBP及MAP水平差异有统计学意义(P,<,0.05)。⑤组间治疗后比较,FPG、2 hPPG、HbA1c及HOMA-IR水平差异有统计学意义(P,<,0.05)。⑥组间治疗后比较,TG水平差异有统计学意义(P,<,0.05) 结论：益气化聚颗粒联合西药治疗代谢综合征微量白蛋白尿,可有效控制疾病的进展,提高胰岛素敏感性,减轻中心性肥胖程度。

Abstract

Objective:To observe the clinical efficacy of “Yiqi Huaju Granules” and western medicine for the treatment of metabolic syndrome coupled with microalbuminuria Methods:One hundred cases with were randomized into treatment group and control group, with 50 cases in each group. The treatment group was treated with western medicine and “Yiqi Huaju Granules”, and the control group was treated with western medicine and placebo, with the course of 12 weeks. The negative conversion ratio of microalbuminuria was observed, and the indicators of urine (MA, UACR, 24 hTP, urinary transferring and β,2, microglobulin), signs indicators (BMI, WHR, SBP, DBP, MAP), and blood sugar (FPG, 2 hPPG, HbA1c, HOMA-IR) and blood fat (TC, TG, LDL, HDL) were compared Results:①All of the 100 subjects completed the clinical study. ②The total negative conversion rate of MA was 28.00% in the treatment group and was 10.00% in the control group, with a difference between the two groups (P,<,0.05). ③After treatment, there were significant differences in the levels of MA, UACR, 24 hTP and urinary β,2, microglobulin between the two groups (P,<,0.05). ④After treatment, there were significant differences in the levels of BMI, WHR, SBP and MAP between the two groups (P,<,0.05). ⑤After treatment, there were significant differences in the levels of FPG, 2 hPPG, HbA1c and HOMA-IR between the two groups (P,<,0.05). ⑥After treatment, there were significant differences in TG level between the two groups (P,<,0.05) Conclusion:Combined “Yiqi Huaju Granules” and western medicine is effective to control the progress of the disease, enhance the insulin sensitivity and reduce central obesity in metabolic syndrome coupled with microalbuminuria.

关键词

代谢综合征微量白蛋白尿益气化聚颗粒胰岛素抵抗中心性肥胖

Keywords

metabolic syndromemicroalbuminuria“Yiqi Huaju Granules”insulin resistancecentral obesity

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