Clinical observation of “Bushen Huoxue Formula” on blocking antibody in women with  recurrent abortion

LYU Bei-li; WANG Hai-yan; ZHANG Ting-ting; ZHU Zhi-ling

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Clinical observation of “Bushen Huoxue Formula” on blocking antibody in women with recurrent abortion

更新时间：2022-08-31

- Clinical observation of “Bushen Huoxue Formula” on blocking antibody in women with recurrent abortion
- Shanghai Journal of Traditional Chinese Medicine Vol. 49, Issue 5, Pages: 70-72(2015)
- 作者机构：
  
  1. 上海中医药大学附属岳阳中西医结合医院妇科,上海,200437
  2. 复旦大学附属妇产科医院中西医结合科,上海,200090
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LYU Bei-li, WANG Hai-yan, ZHANG Ting-ting, et al. Clinical observation of “Bushen Huoxue Formula” on blocking antibody in women with recurrent abortion. [J]. Shanghai Journal of Traditional Chinese Medicine 49(5):70-72(2015)
DOI：

LYU Bei-li, WANG Hai-yan, ZHANG Ting-ting, et al. Clinical observation of “Bushen Huoxue Formula” on blocking antibody in women with recurrent abortion. [J]. Shanghai Journal of Traditional Chinese Medicine 49(5):70-72(2015) DOI：

摘要

目的：观察补肾活血方治疗复发性流产的临床疗效方法：将74例复发性流产患者随机分为治疗组(39例)与对照组(35例)。治疗组予补肾活血方治疗,对照组予补肾固冲丸治疗。两组疗程均为4周,观察临床疗效,随访顺产情况,比较血清绒毛膜促性腺激素(HCG)、孕酮(P)及封闭抗体(BA)的变化情况结果： ①治疗组、对照组临床总有效率分别为94.87%和82.86%；组间临床疗效比较,差异有统计学意义(P<0.05)。②组内比较,两组孕6周、7周、8周、9周血HCG水平较治疗前差异均有统计学意义(P<0.05),各孕周血P水平较治疗前差异均无统计学意义(P>0.05)；两组间同期比较,孕7周、8周、9周血HCG水平差异有统计学意义(P<0.05),而各孕周血P水平差异无统计学意义(P>0.05)。③治疗2周后与治疗前组内比较,两组BE-Ab1、BE-Ab2水平差异有统计学意义(P<0.05),而抗CD3-BE、抗CD4-BE、抗CD8-BE水平差异无统计学意义(P>0.05)；治疗2周后组间比较,BE-Ab1、BE-Ab2水平差异有统计学意义(P<0.05),而抗CD3-BE、抗CD4-BE、抗CD8-BE水平差异无统计学意义(P>0.05)。④随访期间,治疗组35例顺利生产,对照组29例顺利生产；两组顺产率比较,差异无统计学意义(P>0.05) 结论：补肾活血方治疗复发性流产的疗效满意,保胎作用显著。

Abstract

Objective:To observe the clinical efficacy of “Bushen Huoxue Decoction” for the treatment of recurrent spontaneous abortion Methods:Seventy-four cases with recurrent spontaneous abortion were randomized into treatment group (n=39) and control group (n=35). Treatment group was treated with “Bushen Huoxue Decoction” and control group was treated with “Bushen Guchong Pills”, with the course of 4 weeks. The clinical efficacy was observed. Condition of natural labor was follow-up visited, and changes of blood HCG, progesterone and blocking antibody were compared before and after treatment Results:The total effective rate was 94.87% in the treatment group and 82.86% in the control group, with a difference between the two groups(P<0.05). ②After treatment, levels of blood HCG was increased along with the increase of gestational age (P<0.05), while blood P levels showed less correlation with time in both groups (P>0.05). And during 7-9 gestational weeks, there was significant difference in the blood HCG levels between the two groups (P<0.05), and no difference was found in blood P level between the two groups (P>0.05). ③ There were significant differences in the levels of BE-Ab1 and BE-Ab2 between treated for 2 weeks and before treatment in both groups (P<0.05), but no significant difference was found in the levels of anti-CD3-BE, anti-CD4-BE and anti-CD8-BE in both groups (P>0.05); after 2 weeks treatment, there were significant differences in the levels of BE-Ab1 and BE-Ab2 between the groups (P<0.05), while no significant difference was found in the levels of anti-CD3-BE, anti-CD4-BE and anti-CD8-BE between the two groups (P>0.05). ④ Thirty-five cases deliveried in the treatment group and 29 cases in the control group. No significant difference was found between the two groups (P>0.05) Conclusion:“Bushen Huoxue Decoction” has positive effect on protecting the fetus and treating recurrent spontaneous abortion.

关键词

复发性流产补肾活血方封闭抗体免疫保护中药安胎性激素

Keywords

recurrent spontaneous abortion“Bushen Huoxue Decoction”blocking antibodyimmunoprotectionmiscarriage prevention with Chinese medicinesex hormone

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Graduate School， Heilongjiang University of Chinese Medicine

Department of Gynecology， The First Hospital Affiliated to Heilongjiang University of Chinese Medicine

Department of Integrated Traditional Chinese and Western Medicine, First Maternity and Infant Health Care Center Affiliated to Tongji University

Department of Reproductive Immunity, First Maternity and Infant Health Care Center Affiliated to Tongji University

Department of Chinese Medical Gynecology, Wenzhou Hospital of Traditional Chinese Medicine

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