Experimental research of “Guizhi Fuling Pills” for the treatment of dysmenorrhea of blood stasis type

WU Xiu-hong; YANG En-long; SUN Ze; PIAO Cheng-yu; HE Lu-wen; ZHANG Shu-xiang

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Experimental research of “Guizhi Fuling Pills” for the treatment of dysmenorrhea of blood stasis type

更新时间：2022-08-31

- Experimental research of “Guizhi Fuling Pills” for the treatment of dysmenorrhea of blood stasis type
- Shanghai Journal of Traditional Chinese Medicine Vol. 49, Issue 5, Pages: 102-105(2015)
- 作者机构：
  
  1. 黑龙江中医药大学中医药研究院,黑龙江,哈尔滨,150040
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WU Xiu-hong, YANG En-long, SUN Ze, et al. Experimental research of “Guizhi Fuling Pills” for the treatment of dysmenorrhea of blood stasis type. [J]. Shanghai Journal of Traditional Chinese Medicine 49(5):102-105(2015)
DOI：

WU Xiu-hong, YANG En-long, SUN Ze, et al. Experimental research of “Guizhi Fuling Pills” for the treatment of dysmenorrhea of blood stasis type. [J]. Shanghai Journal of Traditional Chinese Medicine 49(5):102-105(2015) DOI：

摘要

目的：探讨桂枝茯苓丸对痛经模型的治疗作用方法：采用大鼠静脉注射缩宫素的方法,观察桂枝茯苓丸对大鼠在体子宫平滑肌的影响；采用腹腔注射缩宫素复制小鼠痛经模型,观察桂枝茯苓丸对痛经模型小鼠的影响；采用毛细玻璃管法,观察桂枝茯苓丸对小鼠凝血时间的影响；采用冰水浴及腹腔注射肾上腺素的方法造成大鼠急性血瘀模型,观察桂枝茯苓丸对血液流变学的影响；采用二甲苯致小鼠耳肿胀,观察桂枝茯苓丸的抗炎作用结果：与模型组比较,桂枝茯苓丸各给药组在体子宫平滑肌收缩幅度明显降低(P<0.05),小鼠15 min 内扭体反应发生次数明显减少(P<0.05),小鼠凝血时间明显延长(P<0.05)；全血黏度、血浆黏度、血沉、红细胞电泳时间均明显降低(P<0.05),凝血酶原时间明显延长(P<0.05)；桂枝茯苓丸高、中剂量组小鼠耳肿胀程度明显减小 (P<0.05) 结论：桂枝茯苓丸可明显抑制大鼠在体子宫平滑肌过度收缩,具有止痛、抗凝、改善血液流变状态及抗炎等作用,对痛经具有很好的治疗作用。

Abstract

Objective:To observe the therapeutic effect of “Guizhi Fuling Pills” in treating dysmenorrheal models Methods:Take the method of intravenous of oxytocin to rats, to observe the effect of “Guizhi Fuling Pills” on rats’ uterine smooth muscle in vivo; the rat models of dysmenorrhea were established by intraperitoneal injection of oxytocin, to observe the effect of “Guizhi Fuling Pills” on dysmenorrhea modeld; by using capillary glass tube method, we observed the influence of “Guizhi Fuling Pills” on blood clotting time in mice; acute blood stasis rat models were established by the method of ice water bath and intraperitoneal injection of epinephrine. Observed the hemorheological effects of “Guizhi Fuling Pills” and the anti-inflammatory action of “Guizhi Fuling Pills” on mice ear swelling induced by xylene Results:Compared with the model group, uterine smooth muscle contraction in vivo of each dose group treated with “Guizhi Fuling Pills” were decreased obviously (P<0.05); number of mice body torsion reaction occurred within 15 min were obviously decreased (P<0.05) and blood clotting time in mice were significantly prolonged (P<0.05); the blood viscosity, plasma viscosity, erythrocyte sedimentation rate (ESR) and erythrocyte electrophoresis time (EET) were reduced significantly (P<0.05), and the prothrombin time was prolonged (P<0.05); mice ear swelling in high, middle dose group treated with “Guizhi Fuling Pills” was significantly reduced (P<0.05) Conclusion:“Guizhi Fuling Pills” has obvious effects on inhibition of excessive contraction of rats uterine smooth muscle in vivo, analgesia, anticoagulation and anti-inflammation, and have good therapeutic effects on dysmenorrhea.

关键词

桂枝茯苓丸痛经血瘀治疗作用.

Keywords

“Guizhi Fuling Pills”dysmenorrheablood stasistherapeutic effect

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