Objective:To observe the clinical efficacy of “Zishen Tiaogan Decoction” in the treatment of postpartum depression  Methods:Eighty-four subjects with postpartum depression were randomized into two groups:control group in which 42 cases were treated with Fluoxetine Hydrochloride Capsules, and treatment group in which 42 cases were treated with “Zishen Tiaogan Decoction”, with a course of eight weeks. The clinical efficacy and HAMD scores were evaluated  Results:The overall effective rate was 88.1% in the treatment group and 76.2% in the control group, with better efficacy in the treatment group than that in the control group (P<0.05). After treatment, HAMD scores were significantly reduced in both groups (P<0.05, P<0.01), with lower score in the treatment group than that in the control group (P<0.05)  Conclusion:“Zishen Tiaogan Decoction” is quite effective for postpartum depression.