Yin-Yang property of osteoblast and osteoclast in bone homeostasis

ZHAO Dong-feng; XING Qiu-juan; WANG Jing; SHU Bing; TANG De-zhi; LI Xiao-feng; SHI Qi; FENG Xu; WANG Yong-jun

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Yin-Yang property of osteoblast and osteoclast in bone homeostasis

更新时间：2022-08-31

- Yin-Yang property of osteoblast and osteoclast in bone homeostasis
- Shanghai Journal of Traditional Chinese Medicine Vol. 49, Issue 4, Pages: 5-10(2015)
- 作者机构：
  
  1. 上海中医药大学附属龙华医院,上海,200032
  2. 美国阿拉巴马大学伯明翰校区,伯明翰,美国,35294
  3. 上海中医药大学脊柱病研究所,上海,200032
  4. 上海中医药大学附属龙华医院石筱山伤科学术研究中心,上海,200032
- 作者简介：
- 基金信息：
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ZHAO Dong-feng, XING Qiu-juan, WANG Jing, et al. Yin-Yang property of osteoblast and osteoclast in bone homeostasis. [J]. Shanghai Journal of Traditional Chinese Medicine 49(4):5-10(2015)
DOI：

ZHAO Dong-feng, XING Qiu-juan, WANG Jing, et al. Yin-Yang property of osteoblast and osteoclast in bone homeostasis. [J]. Shanghai Journal of Traditional Chinese Medicine 49(4):5-10(2015) DOI：

摘要

从成骨细胞和破骨细胞来源的同一性,其间存在的生、克、制、化关系,阳性、阴性调控因子,阴阳属性的相对性等方面,阐释骨稳态中成骨细胞、破骨细胞的阴阳属性。认为成骨细胞和破骨细胞在骨稳态内是典型的阴阳关系,成骨细胞及其主导的骨生成属于“阴”,破骨细胞及其主导的骨吸收属于“阳”,二者动态平衡发挥维持骨稳态的作用。

Abstract

This paper aims to use the application of Yin-Yang theory in bone remodeling to address the nature of Yin-Yang theory in TCM. Here we propose that osteoblasts (bone-forming cells) and bone formation should be considered Yin, while osteoclasts (bone-resorbing cells) and bone resorption should be regarded as Yang. Moreover, we argue that the Yin-Yang relationship exists between osteoblasts and osteoclasts, and we conclude that the relationship between osteoblasts and osteoclasts as established in contemporary biology reflects the classic Yin-Yang in bone homeostasis. Therefore, the new Yin-Yang concept of osteoblasts and osteoclasts in bone homeostasis may strengthen the basic theory of TCM as well as guide clinical practice.

关键词

骨稳态成骨细胞破骨细胞阴阳学说

Keywords

bone homeostasisosteoblastosteoclastYin-Yang theory

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