Objective:To investigate the relationship between interleukin 6(IL-6)and activation-induced cytidine deaminase (AICD) in precancerous lesions in colorectal cancer, to investigate the prevention and treatment role of “Xiaotan Tongfu Decoction” in the treatment of precancerous lesions in colorectal cancer  Methods:Based on the classic AOM/DSS model of precancerous lesions in colorectal cancer, C57BL/6 mice were randomly divided into control group, model group, TCM (“Xiaotan Tongfu Decoction”) group, WM (sulfasalazine) group, integrative medicine group. Control group and model group were given the same amount of distilled water. TCM group were given medicine “Xiaotan Tongfu Decoction” 26 g/(kg.d), concentrate 0.2ml/d; WM group were given sulfasalazine 7.8 mg/pcs/day. Integrative group were given both “Xiaotan Tongfu Decoction” and sulfasalazine. Continuous administration of 12w  Results:Compared with the normal group, the IL-6 and AICD immunohistochemical index, serum protein expression in the model group were increased, the difference was statistically significant (P<0.01). Compared with the model group, 18w IL-6 and AICD immunohistochemical index, serum protein in the TCM medicine group, WM group, Integrative Medicine group were decreased, the difference was statistically significant (P<0.05). Compared with WM group, 18w TCM group AICD immunohistochemical expression index decreased, the difference was statistically significant (P<0.05)  Conclusion:“Xiaotan Tongfu Decoction” reduce the expression of inflammatory cytokines IL-6 and AICD, thereby reducing the occurrence of somatic hypermutation (somatic hypermutation, SHM) and class switch recombination (class-switch recombination, CSR), playing the role of prevention and treatment of Precancerous lesions in colorectal cancer.