Clinical observation of “Yiqi Huoxue Zhuanggu Formula” on bone mineral density and bone metabolism of elder patients with osteoporosis complicated with stable coronary heart disease

CAI Ya-jun; DENG Dun

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Clinical observation of “Yiqi Huoxue Zhuanggu Formula” on bone mineral density and bone metabolism of elder patients with osteoporosis complicated with stable coronary heart disease

更新时间：2022-08-31

- Clinical observation of “Yiqi Huoxue Zhuanggu Formula” on bone mineral density and bone metabolism of elder patients with osteoporosis complicated with stable coronary heart disease
- Shanghai Journal of Traditional Chinese Medicine Vol. 49, Issue 3, Pages: 43-45(2015)
- 作者机构：
  
  1. 浙江省温岭市中医院中医科,浙江温岭,317500
  2. 浙江省温岭市第一人民医院骨科,浙江温岭,317500
- 作者简介：
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CAI Ya-jun, DENG Dun. Clinical observation of “Yiqi Huoxue Zhuanggu Formula” on bone mineral density and bone metabolism of elder patients with osteoporosis complicated with stable coronary heart disease. [J]. Shanghai Journal of Traditional Chinese Medicine 49(3):43-45(2015)
DOI：

CAI Ya-jun, DENG Dun. Clinical observation of “Yiqi Huoxue Zhuanggu Formula” on bone mineral density and bone metabolism of elder patients with osteoporosis complicated with stable coronary heart disease. [J]. Shanghai Journal of Traditional Chinese Medicine 49(3):43-45(2015) DOI：

摘要

目的：观察益气活血壮骨方联合西药治疗冠心病稳定期合并骨质疏松症的临床疗效。方法：将200例冠心病稳定期合并骨质疏松症患者按随机数字表分为治疗组与对照组,每组100例。对照组予常规西医冠心病及抗骨质疏松治疗,治疗组在对照组治疗措施基础上加用益气活血壮骨方。两组疗程均为3个月,观察临床疗效,比较腰椎骨密度(BMD)、骨代谢指标(CTX-1、BGP)及心功能(LVEF、LVEDP)的变化情况。结果：①最终完成试验病例180例,治疗组脱落10例,对照组脱落10例。②治疗组、对照组总有效率分别为91.11%和80.00%,组间临床疗效差异有统计学意义(P＜0.05)。③治疗前后组内比较,两组BMD、CTX-1、BGP水平及心功能指标(LVEF、LVEDP)差异均有统计学意义(P<0.05)；组间治疗后比较,BMD、CTX-1、BGP水平及心功能指标(LVEF、LVEDP)差异有统计学意义(P<0.05)。结论：益气活血壮骨方联合西药治疗冠心病稳定期合并骨质疏松症,疗效满意,可显著提高骨密度,改善骨代谢及心功能。

Abstract

Objective: To observe the clinical efficacy of “Yiqi Huoxue Zhuanggu Formula” and western medicine in treating coronary heart disease (CHD) in stable phase complicated with osteoporosis. Methods Two hundred cases with stable CHD complicated with osteoporosis were randomized into treatment group and control group by random number table, with 100 cases in each group. Control group was treated with western medicine, and treatment group was treated with “Yiqi Huoxue Zhuanggu Formula” additionally, with the course of 3 months. The clinical efficacy, and changes of bone mineral density (BMD), bone metabolism indexes (CTX-1, BGP) and cardiac function indexes (LVEF, LVEDP) were observed and compared before and after treatment. Results: ① One hundred finished the trail. Ten cases in the treatment group were lost, and 10 cases in the control group were lost. ② The total effective rate was 91.11% in the treatment group and 80.00% in the control group, with significant difference between the two groups (P＜0.05). ③ In both groups, there were significant differences in the levels of BMD, CTX-1 and BGP, and cardiac function indexes (LVEF, LVEDP) between before and after treatment (P<0.05); after treatment, there were significant differences in the levels of BMD, CTX-1, BGP and cardiac function indexes (LVEF, LVEDP) between the two groups (P<0.05). Conclusion: Combined “Yiqi Huoxue Zhuanggu Formula” and western medicine is effective to treat coronary heart disease (CHD) complicated with osteoporosis by improving bone mineral density, bone metabolism and cardiac function.

关键词

骨质疏松症冠心病稳定期益气活血壮骨方骨密度骨代谢

Keywords

osteoporosisstable coronary heart disease“Yiqi Huoxue Zhuanggu Formula”bone mineral densitybone metabolism

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