Objective:To explore the similarities and differences of the metabonomics of yin deficiency liver-kidney pattern among kidney diseases, and to discuss the objective material basis of “ the same pattern in different diseases” on small molecules metabolites and relationship between disease and pattern. MethodsUltra performance liquid chromatography- mass spectrum (UPLC-MS) technology was adopted to test the blood metabolites on those with chronic kidney failure, chronic nephritis, chronic urinary tract infections and diabetic nephropathy of yin deficiency liver-kidney pattern. Meanwhile, partial-least-squares method was used to gain categorized statistics of the samples and difference variables by comparing that of healthy people. Common and unique difference variables were known by comparing of difference variables in each pathological group. The result was compared against the data in HMDB and Wiki Pathways database to identify those characteristic metabolites and corresponding metabolic pathways.  Results:Patients with kidney diseases of yin deficiency liver-kidney pattern share four metabolites which are different from healthy people, namely 2-(hydroxyl diethanolamine)- Propionic acid, L- homocysteine, palmitic acid and Diguanosine tetraphosphate and 57 characteristic metabolites, among which 18 chronic kidney failure, 16 chronic nephritis, 14 chronic urinary tract infections and 9 diabetic nephropathy.  Conclusion:The theory of “same pattern among different diseases” is objective and fact-based in chronic renal diseases. The same syndrome could be traced to the consistent material basis (biomarker), while the different diseases to different material basis. “Diseases” and “pattern” both have an impact on patients' metabolism, especially the “diseases”.