Objective: To observe the anti-thrombus function of ginkgolide B drug eluting stent in models. Methods ① Detection of anticoagulation effect in vitro:2 ml sodium citrate anticoagulation was dripped into tubes. We will take ginkgolide B and 316L bare metal stents for comparison. The APTT, PT, and TT were detected in each group for 3 times. ② Arteriovenous shunt models:a healthy pig was used to establish the model and divided into two groups:ginkgolide B stent group and 316L bare metal stent group. The thrombosis in each group was observed by electric magnifier. ③ Model of high load thrombosis:two healthy pigs were used to establish the models and divided into ginkgolide B stent group and 316L bare metal stent group, each group was treated with corresponding measures. The time of thrombosis in each group was observed.  Results: ① APTT time and TT time were significantly prolonged in ginkgolide B coating group in vitro. ② Results in arteriovenous shunt thrombosis models showed that the weight of stent thrombosis was lighter in Ginkgolide B drug eluting stent compared with 316 L bare metal. ③ Results in high load thrombosis models showed that the ginkgolide B drug eluting stent in an average of (140.7±12.3) seconds stent thrombosis, and corresponding 316L stents an average of (52.7±6) seconds stent thrombosis, with a statistical difference between the two groups (P<0.05).  Conclusion: Ginkgolide B drug eluting stent has good anti thrombosis effect, which is expected to be a coating drug in eluting stent selection.