Correlation between TCM patterns of chronic glomerulonephritis and immunological parameters

CAO bei; ZHOU Qing-hua; WANG Chen; BAO Yu-fang; GU Xiang-hua; AI Xi; ZHU Wei-hong

您当前的位置：

首页 >

文章列表页 >

Correlation between TCM patterns of chronic glomerulonephritis and immunological parameters

更新时间：2022-08-31

- Correlation between TCM patterns of chronic glomerulonephritis and immunological parameters
- Shanghai Journal of Traditional Chinese Medicine Vol. 49, Issue 2, Pages: 10-13(2015)
- 作者机构：
  
  1. 上海市浦东新区人民医院中医科,上海,201299
  2. 上海中医药大学附属曙光医院肾病科,上海,200021
- 作者简介：
- 基金信息：
- DOI：
  CLC：
扫描看全文
CAO bei, ZHOU Qing-hua, WANG Chen, et al. Correlation between TCM patterns of chronic glomerulonephritis and immunological parameters. [J]. Shanghai Journal of Traditional Chinese Medicine 49(2):10-13(2015)
DOI：

CAO bei, ZHOU Qing-hua, WANG Chen, et al. Correlation between TCM patterns of chronic glomerulonephritis and immunological parameters. [J]. Shanghai Journal of Traditional Chinese Medicine 49(2):10-13(2015) DOI：

摘要

目的：探讨慢性肾炎中医证型与T淋巴细胞亚群、免疫球蛋白及补体的相关性,为慢性肾炎中医辨证提供客观依据方法：选取120例慢性肾炎患者为评价对象(慢性肾炎组),并选择40例健康人为对照组,同步检测两组的T淋巴细胞亚群、免疫球蛋白及补体,并按照中医证型进行相关性分析结果：与健康组比较,慢性肾炎组患者血IgA、IgG、C3、CD3,+,、CD4,+,、CD4,+,/CD8,+,水平降低,CD8,+,水平增高(P,<,0.05,P,<,0.01)；其中,慢性肾炎患者的IgA、IgG、CD3,+,、CD4,+,、CD4,+,/CD8,+,水平在脾肾阳虚型中最低、脾肾气虚型次之、肝肾阴虚型最高,C3在肺肾气虚型中最低,CD8,+,水平在肝肾阴虚型中最低、脾肾阳虚型中最高,差异均有统计学意义(P,<,0.05,P,<,0.01) 结论：T淋巴细胞亚群、免疫球蛋白及补体水平等免疫学客观指标与慢性肾炎有关,且与中医证型存在明显的相关性,提示慢性肾炎阴阳失衡中存在免疫功能缺陷。

Abstract

Objective: To discuss the correlation between TCM patterns of chronic glomerulonephritis and immunological parameters including T-lymphocyte subsets, immunoglobulin and complement, and to provide an Objective: basis for TCM differentiation of chronic glomerulonephritis Methods: One hundred and twenty cases with chronic nephritis as the evaluation objects, with 40 cases of healthy people as the control group. T lymphocyte subsets, immunoglobulin and complement were detected, and correlation between the two groups according to TCM patterns was analyzed Results: Compared with the healthy group, the levels of IgA, IgG, C3, CD3,+, CD4,+, and CD4,+,/CD8,+, were reduced in the chronic glomerulonephritis group, but the CD8,+, level was increased (P,<,0.05, P,<,0.01); IgA, IgG, CD3,+, CD4,+, and CD4,+,/CD8,+, levels of patients with chronic glomerulonephritis is the lowest in the pattern of yang deficiency of spleen and kidney, followed by the pattern of qi deficiency of spleen and kidney, and the highest in the pattern of yin deficiency of liver and kidney. C3 level is the lowest in the pattern of qi deficiency of lung and kidney. CD8,+, level is the lowest in the pattern of yin deficiency of liver and kidney, and the highest in the pattern of yang deficiency of spleen and kidney. These difference showed statistically significant (P,<,0.05, P,<,0.01).Conclusion There has relationship among T lymphocyte subsets, immunoglobulin, complement and chronic glomerulonephritis. There is a clear correlation between TCM patterns and immunological parameters. Our sampl Results: that patients with chronic nephritis have an imbalance of yin and yang, which may be associate with the immune dysfunction.

关键词

慢性肾炎T淋巴细胞亚群免疫球蛋白补体中医证型

Keywords

chronic nephritisT-lymphocyte subsetimmunoglobulincomplementTCM pattern

references

Views

496

下载量

CSCD

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical research on the effects of “Qiqing Xiaodian Decoction” on the level of immunoglobulin and complement in allergic purpura patients

Research on regularity of syndrome-treatment and prescription-drugs of proteinuria in chronic nephritis in contemporary Chinese medicine based on data mining

Modified Shuanglu Recipe combined with Shenqi Dihuang Decoction in the treatment of IgA nephropathy proteinuria with deficiency of both qi and yin:A randomized,single blind and cross-over study

Effects of five kinds extracts of deer antler base on immunological function in H₂₂ tumor bearing mice

One proven case of nephropathy treated by Gao Ji’ning with syndrome differentiation of six meridians

Related Author

No data

Related Institution

Department of Hematology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine

Department of Traditional Chinese Medicine, Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine

Department of Traditional Chinese medicine, Ruijin Hospital Affiliated to Shanghai Jiao Tong University

Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

Department of Internal Medicine of Traditional Chinese Medicine, Cangzhou Hospital of Integrated TCM-·, Cangzhou, Hebei Province

⁰