苦参的化学成分及生物活性研究进展

李凡; 杨远贵; 谷丽华; 杨莉; 王峥涛

doi:10.16305/j.1007-1334.2021.2103017

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苦参的化学成分及生物活性研究进展

综述 | 更新时间：2022-08-03

- 苦参的化学成分及生物活性研究进展
- Advances in chemical constituents and bioactivities of Sophorae Flavescentis Radix
- 上海中医药杂志 2021年55卷第10期页码：84-100
- 作者机构：
  
  1.上海中医药大学中药研究所中药标准化教育部重点实验室，国家中医药管理局中药新资源与质量评价重点实验室，上海中药标准化研究中心（上海　201203）
- 作者简介：
  
  李凡，女，硕士研究生，主要从事中药质量标准研究工作
  谷丽华，副研究员，硕士研究生导师；E-mail：gulihua1228@163.com。
  王峥涛，教授，博士研究生导师；E-mail:ztwang@shutcm.edu.cn
- 基金信息：
  
  上海市卫健委进一步加快中医药事业发展三年行动计划项目(ZY〔2018-2020〕-CCCX-5002);国家药典委员会标准项目(2018Z003)
- DOI：10.16305/j.1007-1334.2021.2103017
  中图分类号：
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李凡, 杨远贵, 谷丽华, 等. 苦参的化学成分及生物活性研究进展[J]. 上海中医药杂志, 2021,55(10):84-100.

Fan LI, Yuangui YANG, Lihua GU, et al. Advances in chemical constituents and bioactivities of Sophorae Flavescentis Radix[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(10):84-100.
李凡, 杨远贵, 谷丽华, 等. 苦参的化学成分及生物活性研究进展[J]. 上海中医药杂志, 2021,55(10):84-100. DOI： 10.16305/j.1007-1334.2021.2103017.

Fan LI, Yuangui YANG, Lihua GU, et al. Advances in chemical constituents and bioactivities of Sophorae Flavescentis Radix[J]. Shanghai Journal of Traditional Chinese Medicine, 2021,55(10):84-100. DOI： 10.16305/j.1007-1334.2021.2103017.

摘要

苦参为常用清热燥湿药，临床上内服多用于治疗湿热实证，外用多用于治疗皮肤病及妇科疾病。苦参含有多种化学成分，且新的化学成分不断被发现。通过查阅CNKI、Web of Science、PubMed、SciFinder、Sci-hub、i-Data、Microsoft Academic、ResearchGate等数据库，追踪自1953年至今的苦参化学成分研究文献，系统整理了苦参化学成分、结构及其取代基，并对具有构效关系化合物的生物活性进行了阐述。苦参的化学成分包括生物碱、黄酮、苯丙素、二苯甲酰基衍生物、萜类、甾体、有机酸、脂肪酸、挥发油等类型，其中生物碱和黄酮类成分是其主要的结构类型，在抗菌、抗炎、抗病毒和抗肿瘤方面均有重要研究价值。

Abstract

Sophorae Flavescentis Radix is a commonly used Chinese medicine for clearing heat and drying dampness, which is mainly used for the treatment of damp-heat syndrome by oral administration, or for skin and gynecological diseases by external application. Sophorae Flavescentis Radix contains a variety of chemical constituents, and some new chemical constituents have been isolated and discovered in recent years. The purpose of this paper is to summarize comprehensively the chemical constituents from Sophorae Flavescentis Radix by searching major scientific databases (CNKI, Web of Science, PubMed, SciFinder, Sci-hub, i-Data, Microsoft Academic, and Research Gate) for information published since 1953, and the bioactivities of some chemical constituents were highlighted in the paper. The chemical constituents from Sophorae Flavescentis Radix consist of alkaloids, flavonoids, phenylpropanoids, dibenzoyl derivatives, terpenoids, steroids, organic acids, fatty acids, and volatile oils, among which alkaloids and flavonoids are the principal chemical types, showing huge research value in antibacterial, anti-inflammatory, anti-virus and anti-tumor.

关键词

苦参化学成分生物活性药理作用研究进展综述

Keywords

Sophorae Flavescentis Radixchemical constituentsbioactivitypharmacologic actionresearch advancereview

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